ID   2.1.1.370
DE   [histone H3]-lysine(4) N-dimethyltransferase.
CA   L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-
CA   dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine.
CC   -!- This entry describes enzymes that successively methylate the
CC       L-lysine(4) residue of histone H3 (H3K4) twice, ultimately generating
CC       a dimethylated form.
CC   -!- These modifications influence the binding of chromatin-associated
CC       proteins.The human NSD3 protein also catalyzes the activity of
CC       EC 2.1.1.371. cf. EC 2.1.1.354 and EC 2.1.1.364.
DR   Q9BZ95, NSD3_HUMAN ;  Q6P2L6, NSD3_MOUSE ;
//