ID   2.1.1.371
DE   [histone H3]-lysine(27) N-dimethyltransferase.
CA   L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) +
CA   N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-
CA   homocysteine.
CC   -!- This entry describes enzymes that successively methylate the
CC       L-lysine(27) residue of histone H3 (H3K27) twice, ultimately
CC       generating a dimethylated form.
CC   -!- These modifications influence the binding of chromatin-associated
CC       proteins.
CC   -!- The human NSD3 protein also catalyzes the activity of EC 2.1.1.370.
CC       Cf. EC 2.1.1.356 and EC 2.1.1.369.
DR   Q9BZ95, NSD3_HUMAN ;  Q6P2L6, NSD3_MOUSE ;
//