ID 2.1.1.372 DE [histone H4]-lysine(20) N-trimethyltransferase. CA L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = 3 H(+) + CA N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L- CA homocysteine. CC -!- The enzyme, characterized from the fission yeast Schizosaccharomyces CC pombe, catalyzes three successive methylations of the L-lysine-20 CC residue of histone H4 (H4K20), forming the trimethylated form. CC -!- The methylation of this site is apparently not involved in the CC regulation of gene expression or heterochromatin function but CC participates in DNA damage response. cf. EC 2.1.1.361 and CC EC 2.1.1.362. DR Q4X1W8, SET9_ASPFU ; Q2TZH4, SET9_ASPOR ; Q0C9E6, SET9_ASPTN ; DR Q2H8D5, SET9_CHAGB ; Q1E9C0, SET9_COCIM ; Q5AZY3, SET9_EMENI ; DR Q4I8C9, SET9_GIBZE ; Q7SBJ9, SET9_NEUCR ; Q0U3A4, SET9_PHANO ; DR Q9USK2, SET9_SCHPO ; Q6C519, SET9_YARLI ; Q5ZIZ2, SMYD5_CHICK; DR F1RET2, SMYD5_DANRE; Q6GMV2, SMYD5_HUMAN; Q3TYX3, SMYD5_MOUSE; DR Q6GPQ4, SMYD5_XENLA; //