ID   2.1.1.374
DE   2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase.
CA   2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine =
CA   2-heptyl-1-methoxy-4(1H)-quinolinone + H(+) + S-adenosyl-L-homocysteine.
CC   -!- The enzyme, found in mycobacteria, is a member of a family of
CC       heterocyclic toxin methyltransferases.
CC   -!- It is involved in defense against several antimicrobial natural
CC       compounds and drugs.
CC   -!- 4-Hydroxyquinolin-2(1H)-one, 2-heptylquinolin-4(1H)-one, 2-heptyl-3-
CC       hydroxyquinolin-4(1H)-one (the "Pseudomonas quinolone signal", PQS)
CC       and the flavonol quercetin are also O-methylated, albeit with lower
CC       activity.
CC   -!- The enzyme also N-methylates the bactericidal compound 3-methyl-1-
CC       oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-
CC       dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile.
DR   B1MCE2, HTM_MYCA9  ;  A1KG37, HTM_MYCBP  ;  A5TZU0, HTM_MYCTA  ;
DR   P9WKL4, HTM_MYCTO  ;  P9WKL5, HTM_MYCTU  ;
//