ID   2.1.1.375
DE   NNS virus cap methyltransferase.
CA   a 5'-end (5'-triphosphoguanosine)-adenylyl-adenylyl-cytidylyl-adenosine
CA   in mRNA + 2 S-adenosyl-L-methionine = a 5'-end (N(7)-methyl
CA   5'-triphosphoguanosine)-(2'-O-methyladenylyl)-adenylyl-cytidylyl-
CA   adenosine in mRNA + 2 S-adenosyl-L-homocysteine + H(+).
CC   -!- The enzyme from non-segmented negative strain (NNS) viruses (e.g.
CC       rhabdoviruses) catalyzes two successive methylations.
CC   -!- In higher eukaryotes the two methylations occur in the reverse order
CC       and are catalyzed by two different enzymes (cf. EC 2.1.1.56 and
CC       EC 2.1.1.57) that do not required a specific motif.
DR   P35946, L_PHODV    ;  Q0GBX5, L_RABVD    ;
//