ID 2.1.1.379 DE [methyl coenzyme M reductase]-L-arginine C-5-methyltransferase. AN methanogenesis marker protein 10. CA AH2 + L-arginyl-[methyl-coenzyme M reductase] + 2 S-adenosyl-L-methionine CA = (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + CA 5'-deoxyadenosine + A + 2 H(+) + L-methionine + S-adenosyl-L- CA homocysteine. CC -!- The enzyme, present in methanogenic archaea, catalyzes a modification CC of an L-arginine residue at the active site of EC 2.8.4.1, which CC catalyzes the last and methane-releasing step of methanogenesis. CC -!- The enzyme is a radical AdoMet (radical SAM) enzyme and contains an CC [4Fe-4S] cluster and a Coalpha-[alpha-(5-hydroxybenzimidazolyl)]- CC cobamide cofactor. CC -!- The methyl group, which is derived from S-adenosyl-L-methionine, CC is transferred to the cob(I)amide cofactor, forming CC methylcob(III)amide as an intermediate carrier, before being CC transferred to the arginine residue. DR Q8THG6, MCRAM_METAC; Q58251, MCRAM_METJA; //