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ENZYME

ENZYME entry: EC 2.1.1.382

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.382
Accepted Name
methoxylated aromatic compound--corrinoid protein Co-methyltransferase
Reaction catalysed
a methoxylated aromatic compound + Co(I)-[methoxylated-aromatic-compound-specific corrinoid protein] + H(+) = a phenol + methyl-Co(III)-[methoxylated-aromatic-compound-specific corrinoid protein]
Comment(s)
  • This entry stands for a family of enzymes that have been characterized from acetogenic bacteria and archaeal species.
  • Different members of this family have different substrate specificity.
  • In the methanogenic archaeon Methermicoccus shengliensis the enzyme participates in methanogenesis from methoxylated aromatic compounds, while in acetogenic bacteria and in non-methanogenic archaea it participates in methoxydotrophic growth.
  • Most of the enzymes have a wide specificity and were shown to act on a large number of methoxylated aromatic compounds, carrying a methoxy group at positions 2, 3 or 4 of the aromatic ring.
  • Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state; during methylation the cobalt is oxidized to the Co(III) state.
Cross-references
BRENDA2.1.1.382
EC2PDB2.1.1.382
ExplorEnz2.1.1.382
KEGG Ligand Database for Enzyme Nomenclature2.1.1.382
IUBMB Enzyme Nomenclature2.1.1.382
MEDLINEFind literature relating to 2.1.1.382
MetaCyc2.1.1.382
Rhea expert-curated reactions2.1.1.382

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-