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ENZYME

ENZYME entry: EC 2.1.1.386

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.386
Accepted Name
small RNA 2'-O-methyltransferase
Reaction catalysed
small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • The enzyme adds a 2'-O-methyl group to the ribose of the last nucleotide in several types of small RNAs (sRNAs), protecting the 3'-end of sRNAs from uridylation activity and subsequent degradation.
  • Formerly EC 2.1.1.n8.
Cross-references
BRENDA2.1.1.386
EC2PDB2.1.1.386
ExplorEnz2.1.1.386
KEGG Ligand Database for Enzyme Nomenclature2.1.1.386
IUBMB Enzyme Nomenclature2.1.1.386
MEDLINEFind literature relating to 2.1.1.386
MetaCyc2.1.1.386
Rhea expert-curated reactions2.1.1.386
UniProtKB/Swiss-Prot
Q9C5Q8, HEN1_ARATHH9JDT2, HENMT_BOMMOP34283, HENMT_CAEEL
E1BVR9, HENMT_CHICKQ568P9, HENMT_DANREQ7K175, HENMT_DROME
Q5T8I9, HENMT_HUMANQ4R3W5, HENMT_MACFAQ8CAE2, HENMT_MOUSE
Q32PY6, HENMT_RATQ9UST9, HENMT_SCHPOQ230X8, HENMT_TETTS
C0IN03, HENMT_XENTR

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-