ID   2.1.1.394
DE   2-(S-pantetheinyl)-carbapenam-3-carboxylate methyltransferase.
CA   (1) (2R,3R,5R)-2-(S-pantetheinyl)-carbapenam-3-carboxylate + AH2 +
CA   2 S-adenosyl-L-methionine = (2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-
CA   carbapenam-3-carboxylate + 5'-deoxyadenosine + L-methionine + A +
CA   S-adenosyl-L-homocysteine + 2 H(+).
CA   (2) (2R,3R,5S,6R)-6-(methyl)-2-(S-pantetheinyl)-carbapenam-3-carboxylate
CA   + AH2 + 2 S-adenosyl-L-methionine = (2R,3R,5S,6R)-6-(ethyl)-2-
CA   (S-pantetheinyl)-carbapenam-3-carboxylate + 5'-deoxyadenosine +
CA   L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+).
CC   -!- A radical SAM (AdoMet) enzyme that catalyzes two consecutive
CC       methylations during the biosynthesis of complex carbapenem
CC       antibiotics.
CC   -!- The enzyme adds a methyl group at position 6, followed by a second
CC       methylation that converts the methyl group to an ethyl group.
CC   -!- The enzyme binds a [4Fe-4S] cluster and requires a cobalamin cofactor
CC       and an electron donor.
CC   -!- Methyl viologen can be used in vitro.
DR   Q83XP3, THNK_STREN ;
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