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ENZYME

ENZYME entry: EC 2.1.1.397

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.397
Accepted Name
hydroxystrychnine O-methyltransferase
Reaction catalysed
10-hydroxystrychnine + S-adenosyl-L-methionine = beta-colubrine + S-adenosyl-L-homocysteine + H(+)
Comment(s)
  • The enzyme, isolated from the tree Strychnos nux-vomica, participates in the biosynthesis of brucine.
  • It can methylate 10-hydroxystrychnine, and, with lower efficiency, 11-hydroxystrychnine and 11-demethylbrucine.
Cross-references
BRENDA2.1.1.397
EC2PDB2.1.1.397
ExplorEnz2.1.1.397
KEGG Ligand Database for Enzyme Nomenclature2.1.1.397
IUBMB Enzyme Nomenclature2.1.1.397
MEDLINEFind literature relating to 2.1.1.397
MetaCyc2.1.1.397
Rhea expert-curated reactions2.1.1.397
UniProtKB/Swiss-Prot
P0DO86, OMT_STRNX

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