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ENZYME

ENZYME entry: EC 2.1.1.403

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.403
Accepted Name
methylecgonone synthase
Reaction catalysed
(+)-ecgonone + S-adenosyl-L-methionine = ecgonone methyl ester + S-adenosyl-L-homocysteine
Comment(s)
  • Isolated from the plant Erythroxylum novogranatense.
  • The enzyme, which is highly stereoselective, is involved in cocaine biosynthesis.
  • The substrate, ecgonone, is unstable, and in the absence of the methyltransferase decarboxylates into tropinone.
Cross-references
Rhea expert-curated reactions2.1.1.403
ExplorEnz2.1.1.403
IUBMB Enzyme Nomenclature2.1.1.403
BRENDA2.1.1.403
MetaCyc2.1.1.403
KEGG Ligand Database for Enzyme Nomenclature2.1.1.403
EC2PDB2.1.1.403
MEDLINEFind literature relating to 2.1.1.403

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-