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ENZYME

ENZYME entry: EC 2.1.1.41

Accepted Name
sterol 24-C-methyltransferase
Alternative Name(s)
24-sterol C-methyltransferase
Delta(24)-methyltransferase
Delta(24)-sterol methyltransferase
phytosterol methyltransferase
S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase
S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase
SMT1
zymosterol-24-methyltransferase
Reaction catalysed
S-adenosyl-L-methionine + zymosterol = fecosterol + H(+) + S-adenosyl-L-homocysteine
Comment(s)
  • Acts on a range of sterols with a 24(25)-double bond in the side chain.
  • While zymosterol is the preferred substrate it also acts on desmosterol, 5alpha-cholesta-7,24-dien-3beta-ol, 5alpha-cholesta- 5,7,24-trien-3beta-ol, 4alpha-methylzymosterol and others.
  • S-Adenosyl-L-methionine attacks the Si face of the 24(25) double bond and the C-24 hydrogen is transferred to C-25 on the Re face of the double bond.
Cross-references
BRENDA2.1.1.41
EC2PDB2.1.1.41
ExplorEnz2.1.1.41
PRIAM enzyme-specific profiles2.1.1.41
KEGG Ligand Database for Enzyme Nomenclature2.1.1.41
IUBMB Enzyme Nomenclature2.1.1.41
IntEnz2.1.1.41
MEDLINEFind literature relating to 2.1.1.41
MetaCyc2.1.1.41
Rhea expert-curated reactions2.1.1.41
UniProtKB/Swiss-Prot
O74198, ERG6_CANALQ6FRZ7, ERG6_CANGAQ875K1, ERG6_CLAL4
Q6BRB7, ERG6_DEBHAQ759S7, ERG6_EREGSQ6CYB3, ERG6_KLULA
L7IP31, ERG6_PYRO3P0CT10, ERG6_PYRO7O14321, ERG6_SCHPO
Q6C2D9, ERG6_YARLIP25087, ERG6_YEASTQ9LM02, SMT1_ARATH
Q54I98, SMT1_DICDIQ6ZIX2, SMT1_ORYSJ

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