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ENZYME entry: EC 2.1.1.49

Accepted Name
amine N-methyltransferase.
Alternative Name(s)
arylamine N-methyltransferase.
nicotine N-methyltransferase.
tryptamine N-methyltransferase.
Reaction catalysed
  • a primary amine + S-adenosyl-L-methionine <=> a methylated primary amine + H(+) + S-adenosyl-L-homocysteine
  • a secondary amine + S-adenosyl-L-methionine <=> a methylated secondary amine + H(+) + S-adenosyl-L-homocysteine
  • a tertiary amine + S-adenosyl-L-methionine <=> a methylated tertiary amine + H(+) + S-adenosyl-L-homocysteine
Comment(s)
  • An enzyme of very broad specificity; many primary, secondary and tertiary amines can act as acceptors, including tryptamine, aniline, nicotine and a variety of drugs and other xenobiotics.
  • Formerly EC 2.1.1.81.
Cross-references
BRENDA2.1.1.49
EC2PDB2.1.1.49
ExplorEnz2.1.1.49
PRIAM enzyme-specific profiles2.1.1.49
KEGG Ligand Database for Enzyme Nomenclature2.1.1.49
IUBMB Enzyme Nomenclature2.1.1.49
IntEnz2.1.1.49
MEDLINEFind literature relating to 2.1.1.49
MetaCyc2.1.1.49
Rhea expert-curated reactions2.1.1.49
UniProtKB/Swiss-Prot
O95050, INMT_HUMAN;  P40936, INMT_MOUSE;  Q5RFR7, INMT_PONAB;  
O97972, INMT_RABIT;  

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