ENZYME entry: EC 2.1.1.57

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.57

Accepted Name

methyltransferase cap1

Alternative Name(s)

cap1-MTase

messenger RNA (nucleoside-2'-)-methyltransferase

mRNA (nucleoside-2'-O)-methyltransferase

Reaction catalysed

a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)

Comment(s)

This enzyme catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules.
This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses.
The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine.
Formerly EC 2.1.1.58.

Cross-references

BRENDA

2.1.1.57

EC2PDB

2.1.1.57

ExplorEnz

2.1.1.57

KEGG Ligand Database for Enzyme Nomenclature

2.1.1.57

IUBMB Enzyme Nomenclature

2.1.1.57

MEDLINE

Find literature relating to 2.1.1.57

MetaCyc

2.1.1.57

Rhea expert-curated reactions

2.1.1.57

UniProtKB/Swiss-Prot

D2HRF1, CMTR1_AILME	A2VE39, CMTR1_BOVIN	Q803R5, CMTR1_DANRE
Q9W4N2, CMTR1_DROME	Q8N1G2, CMTR1_HUMAN	Q9DBC3, CMTR1_MOUSE
Q5R981, CMTR1_PONAB	Q5U2Z5, CMTR1_RAT	Q6GQ76, CMTR1_XENLA
P41469, CMTR_NPVAC	P15916, MCE_FOWPN	A0A7H0DN74, MCE_MONPV
P68544, MCE_MYXVL	P68545, MCE_MYXVU	P19748, MCE_SHEVK
P23334, MCE_SWPVK	Q76ZT1, MCE_VACCA	P21033, MCE_VACCC
P07617, MCE_VACCW	P33052, MCE_VAR67	A8XYX2, MTR1A_CAEBR
Q9NAA5, MTR1_CAEEL	Q54WR1, MTR1_DICDI	A4HQI9, MTR1_LEIBR
Q4Q089, MTR1_LEIMA	Q38AH0, MTR1_TRYB2	Q4E123, MTR1_TRYCC
Q91B85, POLG_ALKV	C8XPA8, POLG_BANV	Q32ZE0, POLG_BUSV
P27909, POLG_DEN1B	P33478, POLG_DEN1S	P17763, POLG_DEN1W
P29990, POLG_DEN26	P29991, POLG_DEN27	P14337, POLG_DEN28
P07564, POLG_DEN2J	P14340, POLG_DEN2N	P12823, POLG_DEN2P
Q9WDA6, POLG_DEN2Q	Q99D35, POLG_DEN3C	Q5UB51, POLG_DEN3I
Q6YMS3, POLG_DEN3M	P27915, POLG_DEN3P	Q6YMS4, POLG_DEN3S
P09866, POLG_DEN4D	Q2YHF2, POLG_DEN4H	Q58HT7, POLG_DEN4P
Q5UCB8, POLG_DEN4S	Q2YHF0, POLG_DEN4T	C8XPB2, POLG_EHV
Q32ZD7, POLG_ILHV	P27395, POLG_JAEV1	P19110, POLG_JAEV5
P32886, POLG_JAEVJ	G3FEX6, POLG_JAEVM	D7RF80, POLG_KFDV
Q32ZD5, POLG_KOKV	P14335, POLG_KUNJM	P29837, POLG_LANVT
P22338, POLG_LIV	P33515, POLG_MCFA	P05769, POLG_MVEV5
Q7T6D2, POLG_OHFV	Q04538, POLG_POWVL	Q32ZD4, POLG_ROCV
P09732, POLG_STEVM	Q01299, POLG_TBEVH	P07720, POLG_TBEVS
P14336, POLG_TBEVW	G1CRV4, POLG_TMUV	Q5WPU5, POLG_USUV
P06935, POLG_WNV	Q9Q6P4, POLG_WNV9	C5H431, POLG_WSLV
P03314, POLG_YEFV1	Q6DV88, POLG_YEFVA	Q6J3P1, POLG_YEFVC
Q074N0, POLG_YEFVE	Q89277, POLG_YEFVF	Q98803, POLG_YEFVI
Q1X881, POLG_YEFVN	Q9YRV3, POLG_YEFVT	Q1X880, POLG_YEFVU
Q32ZE1, POLG_ZIKV	A0A024B7W1, POLG_ZIKVF	A0A142I5B9, POLG_ZIKVK
F8RL29, R1AB_AMV79	P0C6W1, R1AB_BC133	P0C6V9, R1AB_BC279
P0C6W0, R1AB_BC512	P0C6W2, R1AB_BCHK3	P0C6W3, R1AB_BCHK4
P0C6W4, R1AB_BCHK5	P0C6W5, R1AB_BCHK9	P0C6W6, R1AB_BCRP3
P0C6W7, R1AB_CVBEN	P0C6W8, R1AB_CVBLU	P0C6W9, R1AB_CVBM
P0C6X0, R1AB_CVBQ	P0C6X1, R1AB_CVH22	P0C6X2, R1AB_CVHN1
P0C6X3, R1AB_CVHN2	P0C6X4, R1AB_CVHN5	P0C6X5, R1AB_CVHNL
P0C6X6, R1AB_CVHOC	P0C6X8, R1AB_CVM2	P0C6X9, R1AB_CVMA5
P0C6Y0, R1AB_CVMJH	P0C6Y5, R1AB_CVPPU	Q98VG9, R1AB_FIPV
P0C6Y1, R1AB_IBVB	P0C6Y2, R1AB_IBVBC	P0C6Y3, R1AB_IBVM
K9N7C7, R1AB_MERS1	P0C6Y4, R1AB_PEDV7	P0C6X7, R1AB_SARS
P0DTD1, R1AB_SARS2	Q008X6, R1AB_WBV24

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