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ENZYME entry: EC 2.1.1.57

Accepted Name
Methyltransferase cap1.
Alternative Name(s)
Cap1-MTase.
mRNA (nucleoside-2'-O)-methyltransferase.
Reaction catalysed
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] <=> S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA]
Comment(s)
  • This enzyme catalyzes the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules, which may be either guanosine or adenosine.
  • This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses.
  • The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine.
  • Formerly EC 2.1.1.58.
Cross-references
BRENDA2.1.1.57
EC2PDB2.1.1.57
ExplorEnz2.1.1.57
PRIAM enzyme-specific profiles2.1.1.57
KEGG Ligand Database for Enzyme Nomenclature2.1.1.57
IUBMB Enzyme Nomenclature2.1.1.57
IntEnz2.1.1.57
MEDLINEFind literature relating to 2.1.1.57
MetaCyc2.1.1.57
UniProtKB/Swiss-Prot
D2HRF1, CMTR1_AILME;  A2VE39, CMTR1_BOVIN;  Q803R5, CMTR1_DANRE;  
Q8N1G2, CMTR1_HUMAN;  Q9DBC3, CMTR1_MOUSE;  Q5R981, CMTR1_PONAB;  
Q5U2Z5, CMTR1_RAT;  Q6GQ76, CMTR1_XENLA;  P41469, CMTR_NPVAC;  
P15916, MCE_FOWPN;  P68544, MCE_MYXVL;  P68545, MCE_MYXVU;  
P19748, MCE_SHEVK;  P23334, MCE_SWPVK;  Q76ZT1, MCE_VACCA;  
P21033, MCE_VACCC;  P07617, MCE_VACCW;  P33052, MCE_VAR67;  
A8XYX2, MTR1A_CAEBR;  Q9NAA5, MTR1_CAEEL;  Q54WR1, MTR1_DICDI;  
Q9W4N2, MTR1_DROME;  A4HQI9, MTR1_LEIBR;  Q4Q089, MTR1_LEIMA;  
Q38AH0, MTR1_TRYB2;  Q4E123, MTR1_TRYCC;  Q91B85, POLG_ALKV;  
C8XPA8, POLG_BANV;  Q32ZE0, POLG_BUSV;  P27909, POLG_DEN1B;  
P33478, POLG_DEN1S;  P17763, POLG_DEN1W;  P29990, POLG_DEN26;  
P29991, POLG_DEN27;  P14337, POLG_DEN28;  P07564, POLG_DEN2J;  
P14340, POLG_DEN2N;  P12823, POLG_DEN2P;  Q9WDA6, POLG_DEN2Q;  
Q99D35, POLG_DEN3C;  Q5UB51, POLG_DEN3I;  Q6YMS3, POLG_DEN3M;  
P27915, POLG_DEN3P;  Q6YMS4, POLG_DEN3S;  P09866, POLG_DEN4D;  
Q2YHF2, POLG_DEN4H;  Q58HT7, POLG_DEN4P;  Q5UCB8, POLG_DEN4S;  
Q2YHF0, POLG_DEN4T;  C8XPB2, POLG_EHV;  Q32ZD7, POLG_ILHV;  
P27395, POLG_JAEV1;  P19110, POLG_JAEV5;  P32886, POLG_JAEVJ;  
G3FEX6, POLG_JAEVM;  D7RF80, POLG_KFDV;  Q32ZD5, POLG_KOKV;  
P14335, POLG_KUNJM;  P29837, POLG_LANVT;  P22338, POLG_LIV;  
P33515, POLG_MCFA;  P05769, POLG_MVEV5;  Q7T6D2, POLG_OHFV;  
Q04538, POLG_POWVL;  Q32ZD4, POLG_ROCV;  P09732, POLG_STEVM;  
Q01299, POLG_TBEVH;  P07720, POLG_TBEVS;  P14336, POLG_TBEVW;  
Q5WPU5, POLG_USUV;  P06935, POLG_WNV;  Q9Q6P4, POLG_WNV9;  
C5H431, POLG_WSLV;  P03314, POLG_YEFV1;  Q6DV88, POLG_YEFVA;  
Q6J3P1, POLG_YEFVC;  Q074N0, POLG_YEFVE;  Q89277, POLG_YEFVF;  
Q98803, POLG_YEFVI;  Q1X881, POLG_YEFVN;  Q9YRV3, POLG_YEFVT;  
Q1X880, POLG_YEFVU;  Q32ZE1, POLG_ZIKV;  A0A024B7W1, POLG_ZIKVF;  
A0A142I5B9, POLG_ZIKVK;  

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