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ENZYME

ENZYME entry: EC 2.1.1.63

Accepted Name
methylated-DNA--[protein]-cysteine S-methyltransferase
Alternative Name(s)
6-O-methylguanine-DNA methyltransferase
O-6-methylguanine-DNA-alkyltransferase
Reaction catalysed
  • a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] <=> a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]
  • a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] <=> a thymidine in DNA + S-methyl-L-cysteinyl-[protein]
Comment(s)
  • This protein is involved in the repair of methylated DNA.
  • Unlike EC 3.2.2.20 and EC 3.2.2.21, which remove the methylated base leaving an apurinic/apyrimidinic site, this enzyme transfers the methyl group from the methylated DNA to an internal cysteine residue, leaving an intact nucleotide.
  • Since the methyl transfer is irreversible, the enzyme can only catalyze a single turnover.
Cross-references
BRENDA2.1.1.63
EC2PDB2.1.1.63
ExplorEnz2.1.1.63
PRIAM enzyme-specific profiles2.1.1.63
KEGG Ligand Database for Enzyme Nomenclature2.1.1.63
IUBMB Enzyme Nomenclature2.1.1.63
IntEnz2.1.1.63
MEDLINEFind literature relating to 2.1.1.63
MetaCyc2.1.1.63
Rhea expert-curated reactions2.1.1.63
UniProtKB/Swiss-Prot
P19220, ADAB_BACSUP06134, ADA_ECOLIP26189, ADA_SALTY
P29177, MGMT_BOVINQ5A0Y8, MGMT_CANALQ6FNR0, MGMT_CANGB
Q6TDU1, MGMT_CANLFP26186, MGMT_CRIGRQ6BVY4, MGMT_DEBHA
P16455, MGMT_HUMANQ6CPW2, MGMT_KLULCA5E7M8, MGMT_LODEL
Q5UNU9, MGMT_MIMIVP26187, MGMT_MOUSEA3LZM4, MGMT_PICST
P24528, MGMT_RATA6ZXD3, MGMT_YEAS7P26188, MGMT_YEAST
O27970, OGT_ARCFUP11742, OGT_BACSUP0AFH0, OGT_ECOLI
P44687, OGT_HAEINQ8TI34, OGT_METACQ46EW4, OGT_METBF
Q58924, OGT_METJAQ8TZ11, OGT_METKAQ8PY44, OGT_METMA
A4YH39, OGT_METS5O26715, OGT_METTHC9RE37, OGT_METVM
P0A697, OGT_MYCBOP52982, OGT_MYCLEQ9ZET8, OGT_MYCPA
P9WJW4, OGT_MYCTOP9WJW5, OGT_MYCTUQ9V1N7, OGT_PYRAB
O93728, OGT_PYRAEQ8TZV2, OGT_PYRFUO59499, OGT_PYRHO
F4HK38, OGT_PYRSNQ97VW7, OGT_SACS2P0A2U1, OGT_SALTI
P0A2U0, OGT_SALTYP0AFH1, OGT_SHIFLQ4J9C6, OGT_SULAC
C3N1B4, OGT_SULIAC4KKV8, OGT_SULIKC3MKT6, OGT_SULIL
C3MUC6, OGT_SULIMC3NMY2, OGT_SULINC3N9B4, OGT_SULIY
Q973C7, OGT_SULTOF0LIT8, OGT_THEBMC5A3L5, OGT_THEGJ
O74023, OGT_THEKOC6A382, OGT_THESM

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
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