ID 2.1.1.69 DE 5-hydroxyfuranocoumarin 5-O-methyltransferase. AN bergaptol 5-O-methyltransferase. AN bergaptol methyltransferase. AN bergaptol O-methyltransferase. AN BMT. AN furanocoumarin 5-methyltransferase. AN furanocoumarin 5-O-methyltransferase. CA (1) a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine = CA a 5-methoxyfurocoumarin + H(+) + S-adenosyl-L-homocysteine. CA (2) bergaptol + S-adenosyl-L-methionine = bergapten + S-adenosyl-L- CA homocysteine. CC -!- Converts bergaptol into bergapten, which has therapeutic potential in CC the treatment of psoriasis as it has photosensitizing and CC antiproliferative activities. CC -!- Methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, CC such as 5-hydroxyxanthotoxin, but has little activity on non-coumarin CC phenols; caffeate, 5-hydroxyferulate and daphnetin are not CC substrates. CC -!- Cu(2+), Zn(2+) and Co(2+) cause enzyme inhibition. CC -!- See also EC 2.1.1.70. CC -!- Formerly EC 2.1.1.92. DR Q6T1F6, BMT_AMMMJ ; A8J6X1, BMT_GLELI ; A0A166U5H3, BMT_KITPR ; DR A0A4P8DY91, COMTS_KITPR; //