ID 2.1.1.74 DE methylenetetrahydrofolate--tRNA-(uracil(54)-C(5))-methyltransferase DE [NAD(P)H-oxidizing]. AN folate/FAD-dependent tRNA T54 methyltransferase. AN folate-dependent ribothymidyl synthase. CA (1) (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + CA uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) CA in tRNA + NAD(+). CA (2) (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + CA uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) CA in tRNA + NADP(+). CC -!- A flavoprotein (FAD). CC -!- Up to 25% of the bases in mature tRNA are post-translationally CC modified or hypermodified. CC -!- One almost universal post-translational modification is the CC conversion of U(54) into ribothymidine in the TPsiC loop, and this CC modification is found in most species studied to date. CC -!- Unlike this enzyme, which uses 5,10-methylenetetrahydrofolate and CC NAD(P)H to supply the atoms for methylation of U(54), EC 2.1.1.35 CC uses S-adenosyl-L-methionine. CC -!- Formerly EC 2.1.2.12. DR Q6F1M4, TMFO1_MESFL; Q2SS13, TMFO1_MYCCT; Q6MTM6, TMFO1_MYCMS; DR Q6F0T3, TMFO2_MESFL; Q2SRN2, TMFO2_MYCCT; Q6MTB4, TMFO2_MYCMS; DR B0C6V8, TRMFO_ACAM1; A3DCM0, TRMFO_ACET2; A9NHD0, TRMFO_ACHLI; DR Q8UET6, TRMFO_AGRFC; B8JES4, TRMFO_ANAD2; Q2ILE0, TRMFO_ANADE; DR A7HDU6, TRMFO_ANADF; B4UII2, TRMFO_ANASK; B7GGC8, TRMFO_ANOFW; DR O66913, TRMFO_AQUAE; A8ID68, TRMFO_AZOC5; C3P5N4, TRMFO_BACAA; DR C3L795, TRMFO_BACAC; A0RHK5, TRMFO_BACAH; Q81WK3, TRMFO_BACAN; DR B7JJB0, TRMFO_BACC0; Q732N8, TRMFO_BACC1; B7IUJ1, TRMFO_BACC2; DR C1EP56, TRMFO_BACC3; B7HDV5, TRMFO_BACC4; B7HLG5, TRMFO_BACC7; DR A7GRG2, TRMFO_BACCN; B9IVC1, TRMFO_BACCQ; Q819X4, TRMFO_BACCR; DR Q636J4, TRMFO_BACCZ; Q6HEY3, TRMFO_BACHK; Q65JN6, TRMFO_BACLD; DR A9VT70, TRMFO_BACMK; A8FD77, TRMFO_BACP2; P39815, TRMFO_BACSU; DR A7Z4N3, TRMFO_BACVZ; A1USB2, TRMFO_BARBK; Q6G3Y9, TRMFO_BARHE; DR A9ISB8, TRMFO_BART1; Q6MHW5, TRMFO_BDEBA; B2IGU6, TRMFO_BEII9; DR Q89L21, TRMFO_BRADU; A5EJU4, TRMFO_BRASB; A4YV54, TRMFO_BRASO; DR C0ZFA9, TRMFO_BREBN; Q2YNL7, TRMFO_BRUA2; A6X1E3, TRMFO_BRUA4; DR Q57DL3, TRMFO_BRUAB; A9MAR7, TRMFO_BRUC2; P64232, TRMFO_BRUME; DR A5VQ76, TRMFO_BRUO2; B0CLM0, TRMFO_BRUSI; P64233, TRMFO_BRUSU; DR B9MM32, TRMFO_CALBD; A4XIW8, TRMFO_CALS8; Q3AB71, TRMFO_CARHZ; DR B0T866, TRMFO_CAUSK; Q9A566, TRMFO_CAUVC; A3PJ80, TRMFO_CERS1; DR Q3J349, TRMFO_CERS4; A4WRQ2, TRMFO_CERS5; B9KRK8, TRMFO_CERSK; DR Q11HD9, TRMFO_CHESB; B5EHR5, TRMFO_CITBB; B5Y8G1, TRMFO_COPPD; DR B1WR77, TRMFO_CROS5; Q1J148, TRMFO_DEIGD; Q9RXU7, TRMFO_DEIRA; DR B1I258, TRMFO_DESAP; Q24UF0, TRMFO_DESHY; Q6ALS7, TRMFO_DESPS; DR A4J5Z8, TRMFO_DESRM; Q729K0, TRMFO_DESVH; A1VBW6, TRMFO_DESVV; DR B5YFC6, TRMFO_DICT6; B8E2F5, TRMFO_DICTD; A8LK18, TRMFO_DINSH; DR Q834K1, TRMFO_ENTFA; Q2NAC8, TRMFO_ERYLH; B1YIB2, TRMFO_EXIS2; DR C4L614, TRMFO_EXISA; A7HL16, TRMFO_FERNB; Q8REM9, TRMFO_FUSNN; DR B9M5T8, TRMFO_GEODF; Q39X89, TRMFO_GEOMG; Q74A44, TRMFO_GEOSL; DR C6E557, TRMFO_GEOSM; A5G7S3, TRMFO_GEOUR; Q7NFC3, TRMFO_GLOVI; DR Q9KA24, TRMFO_HALH5; B0TH93, TRMFO_HELMI; B4U7L4, TRMFO_HYDS0; DR Q0BYJ6, TRMFO_HYPNA; Q28PE7, TRMFO_JANSC; Q1IHM1, TRMFO_KORVE; DR Q5FKE1, TRMFO_LACAC; Q1G9V1, TRMFO_LACDA; Q04A02, TRMFO_LACDB; DR Q043R6, TRMFO_LACGA; A8YV48, TRMFO_LACH4; Q74JJ8, TRMFO_LACJO; DR Q9CG79, TRMFO_LACLA; A2RKQ0, TRMFO_LACLM; Q02YZ3, TRMFO_LACLS; DR Q039E2, TRMFO_LACP3; Q88W23, TRMFO_LACPL; Q38WZ1, TRMFO_LATSS; DR Q1MQ25, TRMFO_LAWIP; Q1WU04, TRMFO_LIGS1; Q92C76, TRMFO_LISIN; DR Q720E5, TRMFO_LISMF; Q8Y7K1, TRMFO_LISMO; A0AI79, TRMFO_LISW6; DR B1HQJ3, TRMFO_LYSSC; A0LDC6, TRMFO_MAGMM; Q2W4D9, TRMFO_MAGSA; DR Q0ANF3, TRMFO_MARMM; A9VXT4, TRMFO_METEP; B1ZES7, TRMFO_METPB; DR B1M5H7, TRMFO_METRJ; B0UI96, TRMFO_METS4; B0JFX8, TRMFO_MICAN; DR Q2RJP8, TRMFO_MOOTA; A5IXT6, TRMFO_MYCAP; Q9S449, TRMFO_MYXXD; DR B2A334, TRMFO_NATTJ; Q1QMC9, TRMFO_NITHX; Q3SRR6, TRMFO_NITWN; DR Q8YNJ4, TRMFO_NOSS1; Q2G718, TRMFO_NOVAD; Q312C5, TRMFO_OLEA2; DR A1B9F0, TRMFO_PARDP; A7HXL5, TRMFO_PARL1; Q7U7T2, TRMFO_PARMW; DR A1ALD8, TRMFO_PELPD; A5D2W5, TRMFO_PELTS; C0QTE2, TRMFO_PERMH; DR B4RDH0, TRMFO_PHEZH; B1XK17, TRMFO_PICP2; A3PDM1, TRMFO_PROM0; DR A2C3G4, TRMFO_PROM1; A8G5I6, TRMFO_PROM2; A2C8E1, TRMFO_PROM3; DR A9BEK6, TRMFO_PROM4; A2BXA3, TRMFO_PROM5; Q31AA9, TRMFO_PROM9; DR Q7VD04, TRMFO_PROMA; Q7TUW5, TRMFO_PROMM; Q7TU75, TRMFO_PROMP; DR A2BRU5, TRMFO_PROMS; Q46K52, TRMFO_PROMT; A8F516, TRMFO_PSELT; DR Q2K957, TRMFO_RHIEC; Q1MHL2, TRMFO_RHIJ3; Q98LE1, TRMFO_RHILO; DR Q92Q15, TRMFO_RHIME; A5V4M8, TRMFO_RHIWR; O68141, TRMFO_RHOCB; DR Q2IWI0, TRMFO_RHOP2; Q07MJ4, TRMFO_RHOP5; Q6N5Z1, TRMFO_RHOPA; DR Q213W6, TRMFO_RHOPB; Q136I8, TRMFO_RHOPS; Q2RTI8, TRMFO_RHORT; DR Q166D3, TRMFO_ROSDO; Q1ATM0, TRMFO_RUBXD; Q5LST0, TRMFO_RUEPO; DR Q1GGU2, TRMFO_RUEST; Q5WFP8, TRMFO_SHOC1; A6U8P9, TRMFO_SINMW; DR Q02C58, TRMFO_SOLUE; A9FRC1, TRMFO_SORC5; Q1GTZ7, TRMFO_SPHAL; DR A7X1M6, TRMFO_STAA1; A6U169, TRMFO_STAA2; Q2FHI7, TRMFO_STAA3; DR Q2FZ31, TRMFO_STAA8; A5ISD5, TRMFO_STAA9; Q2YXL7, TRMFO_STAAB; DR Q5HGI1, TRMFO_STAAC; A6QGF1, TRMFO_STAAE; P64234, TRMFO_STAAM; DR P64235, TRMFO_STAAN; Q6GHI4, TRMFO_STAAR; Q6G9W2, TRMFO_STAAS; DR A8Z3T1, TRMFO_STAAT; P64236, TRMFO_STAAW; B9DPG3, TRMFO_STACT; DR Q5HPU1, TRMFO_STAEQ; Q8CPH2, TRMFO_STAES; Q4L5V3, TRMFO_STAHJ; DR Q49X36, TRMFO_STAS1; Q3K1B8, TRMFO_STRA1; Q8E5M6, TRMFO_STRA3; DR Q8DZX5, TRMFO_STRA5; C0M6C7, TRMFO_STRE4; A8AXH0, TRMFO_STRGC; DR P05428, TRMFO_STRMU; Q99ZL9, TRMFO_STRP1; Q04KY2, TRMFO_STRP2; DR P0DB36, TRMFO_STRP3; B5E446, TRMFO_STRP4; Q5XC46, TRMFO_STRP6; DR C1C6S2, TRMFO_STRP7; Q8P106, TRMFO_STRP8; Q1JBP0, TRMFO_STRPB; DR Q1JLM2, TRMFO_STRPC; Q1JGS2, TRMFO_STRPD; Q1J6J1, TRMFO_STRPF; DR A2REF7, TRMFO_STRPG; B1IBA6, TRMFO_STRPI; B8ZP43, TRMFO_STRPJ; DR Q48TI1, TRMFO_STRPM; Q97R84, TRMFO_STRPN; P0DB37, TRMFO_STRPQ; DR B2IP98, TRMFO_STRPS; Q8DQ51, TRMFO_STRR6; A4W125, TRMFO_STRS2; DR C0MFF9, TRMFO_STRS7; A3CN32, TRMFO_STRSV; A4VUS8, TRMFO_STRSY; DR Q5M014, TRMFO_STRT1; Q5M4M7, TRMFO_STRT2; Q03KX0, TRMFO_STRTD; DR B9DS62, TRMFO_STRU0; C1CDT9, TRMFO_STRZJ; C1CK27, TRMFO_STRZP; DR C1CRV5, TRMFO_STRZT; B2V9U2, TRMFO_SULSY; Q67PC6, TRMFO_SYMTH; DR Q2LT41, TRMFO_SYNAS; Q3A7H9, TRMFO_SYNC1; Q31NM4, TRMFO_SYNE7; DR Q2JRF7, TRMFO_SYNJA; Q2JQ64, TRMFO_SYNJB; Q5N5J0, TRMFO_SYNP6; DR A5GLJ3, TRMFO_SYNPW; A5GU85, TRMFO_SYNR3; Q0IB24, TRMFO_SYNS3; DR Q3AX63, TRMFO_SYNS9; Q3AIZ7, TRMFO_SYNSC; Q0AYP4, TRMFO_SYNWW; DR Q55692, TRMFO_SYNY3; B7IFU6, TRMFO_THEAB; A6LJK8, TRMFO_THEM4; DR Q9WZJ3, TRMFO_THEMA; B9KAP3, TRMFO_THENN; A5IJ51, TRMFO_THEP1; DR B1L7X2, TRMFO_THESQ; Q72IQ5, TRMFO_THET2; Q5SID2, TRMFO_THET8; DR P59109, TRMFO_THEVB; Q3MA89, TRMFO_TRIV2; A7INE1, TRMFO_XANP2; DR Q5NPP5, TRMFO_ZYMMO; //