ENZYME

ENZYME entry: EC 2.1.1.90

Accepted Name

Methanol--corrinoid protein Co-methyltransferase.

Alternative Name(s)

Methanol--5-hydroxybenzimidazolylcobamide Co-methyltransferase.

Reaction catalysed

Methanol + a [Co(I) methanol-specific corrinoid protein] <=> a [methyl-Co(III) methanol-specific corrinoid protein] + H(2)O

Comment(s)

The enzyme, which catalyzes the transfer of methyl groups from methanol to a methanol-specific corrinoid protein (MtaC), is involved in methanogenesis from methanol.
Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state.
During methylation the cobalt is oxidized to the Co(III) state.
Free cob(I)alamin can substitute for the corrinoid protein in vitro.
Inactivated by oxygen and other oxidizing agents, and reactivated by catalytic amounts of ATP and hydrogen.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature