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ENZYME entry: EC 2.1.1.90

Accepted Name
methanol--corrinoid protein Co-methyltransferase.
Alternative Name(s)
methanol--5-hydroxybenzimidazolylcobamide Co-methyltransferase.
Reaction catalysed
Co(I)-[methanol-specific corrinoid protein] + H(+) + methanol <=> H2O + methyl-Co(III)-[methanol-specific corrinoid protein]
Comment(s)
  • The enzyme, which catalyzes the transfer of methyl groups from methanol to a methanol-specific corrinoid protein (MtaC), is involved in methanogenesis from methanol.
  • Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state.
  • During methylation the cobalt is oxidized to the Co(III) state.
  • Free cob(I)alamin can substitute for the corrinoid protein in vitro.
  • Inactivated by oxygen and other oxidizing agents, and reactivated by catalytic amounts of ATP and hydrogen.
Cross-references
BRENDA2.1.1.90
EC2PDB2.1.1.90
ExplorEnz2.1.1.90
PRIAM enzyme-specific profiles2.1.1.90
KEGG Ligand Database for Enzyme Nomenclature2.1.1.90
IUBMB Enzyme Nomenclature2.1.1.90
IntEnz2.1.1.90
MEDLINEFind literature relating to 2.1.1.90
MetaCyc2.1.1.90
Rhea expert-curated reactions2.1.1.90
UniProtKB/Swiss-Prot
Q46EH3, MTAB_METBF

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