ID   2.1.1.98
DE   diphthine synthase.
CA   2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor
CA   2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor
CA   2] + 3 H(+) + 3 S-adenosyl-L-homocysteine.
CC   -!- This archaeal enzyme produces the trimethylated product diphthine,
CC       which is converted into diphthamide by EC 6.3.1.14.
CC   -!- Different from the eukaryotic enzyme, which produces diphthine methyl
CC       ester (cf. EC 2.1.1.314).
CC   -!- In the archaeon Pyrococcus horikoshii the enzyme acts on His(600) of
CC       elongation factor 2.
DR   Q9YDI2, DPHB_AERPE ;  O29866, DPHB_ARCFU ;  B9LV13, DPHB_HALLT ;
DR   Q5V2B7, DPHB_HALMA ;  B0R4W9, DPHB_HALS3 ;  Q9HQK6, DPHB_HALSA ;
DR   Q18JS3, DPHB_HALWD ;  A6UU49, DPHB_META3 ;  Q8TR14, DPHB_METAC ;
DR   Q0W085, DPHB_METAR ;  A7IA21, DPHB_METB6 ;  Q467Z4, DPHB_METBF ;
DR   Q12XB4, DPHB_METBU ;  Q2FQ45, DPHB_METHJ ;  Q58670, DPHB_METJA ;
DR   Q8TXC7, DPHB_METKA ;  A2SQF6, DPHB_METLZ ;  A4FYP1, DPHB_METM5 ;
DR   A9A6D8, DPHB_METM6 ;  A6VJP1, DPHB_METM7 ;  Q8PUH9, DPHB_METMA ;
DR   A3CWF9, DPHB_METMJ ;  Q6LZN6, DPHB_METMP ;  B8GIF8, DPHB_METPE ;
DR   A4YHI8, DPHB_METS5 ;  Q2NFJ8, DPHB_METST ;  O27902, DPHB_METTH ;
DR   A0B879, DPHB_METTP ;  A6US81, DPHB_METVS ;  Q3IS55, DPHB_NATPD ;
DR   Q9UZ31, DPHB_PYRAB ;  Q8ZXR9, DPHB_PYRAE ;  A3MU14, DPHB_PYRCJ ;
DR   Q8U377, DPHB_PYRFU ;  O58456, DPHB_PYRHO ;  A1RU15, DPHB_PYRIL ;
DR   B1YAU2, DPHB_PYRNV ;  Q97TX8, DPHB_SACS2 ;  A3DLV7, DPHB_STAMF ;
DR   C3N5D1, DPHB_SULIA ;  C4KGZ7, DPHB_SULIK ;  C3MPQ5, DPHB_SULIL ;
DR   C3MYP9, DPHB_SULIM ;  C3NHR8, DPHB_SULIN ;  C3NDY5, DPHB_SULIY ;
DR   Q971V1, DPHB_SULTO ;  Q9HJT0, DPHB_THEAC ;  C5A3K4, DPHB_THEGJ ;
DR   Q5JFE7, DPHB_THEKO ;  B6YXP9, DPHB_THEON ;  Q979Z8, DPHB_THEVO ;
//