ENZYME entry: EC 2.1.3.1
Accepted Name |
Methylmalonyl-CoA carboxytransferase.
|
Alternative Name(s) |
Methylmalonyl-CoA carboxyltransferase. |
Transcarboxylase. |
Reaction catalysed |
(S)-methylmalonyl-CoA + pyruvate <=> propanoyl-CoA + oxaloacetate |
Cofactor(s) |
Biotin; Cobalt cation; Zn(2+).
|
Comment(s) |
- A biotinyl-protein, containing cobalt and zinc.
- The enzyme, described from the bacterium Propionibacterium shermanii,
is unique among the biotin-dependent enzymes in that it catalyzes
carboxyl transfer between two organic molecules, utilizing two
separate carboxyltransferase domains.
- The enzyme is a very large complex, consisting of a hexameric central
core of 12S subunits surrounded by six 5S subunit dimers, each
connected to the central core by twelve 1.3S biotin carrier subunits.
|
Cross-references |
PROSITE | PDOC00167 |
BRENDA | 2.1.3.1 |
EC2PDB | 2.1.3.1 |
ExplorEnz | 2.1.3.1 |
PRIAM enzyme-specific profiles | 2.1.3.1 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.3.1 |
IUBMB Enzyme Nomenclature | 2.1.3.1 |
IntEnz | 2.1.3.1 |
MEDLINE | Find literature relating to 2.1.3.1 |
MetaCyc | 2.1.3.1 |
Rhea expert-curated reactions | 2.1.3.1 |
UniProtKB/Swiss-Prot |
|
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