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ENZYME

ENZYME entry: EC 2.1.3.1

PURL: https://purl.expasy.org/enzyme/EC/2.1.3.1
Accepted Name
methylmalonyl-CoA carboxytransferase
Alternative Name(s)
methylmalonyl-CoA carboxyltransferase
transcarboxylase
Reaction catalysed
(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate
Comment(s)
  • A biotinyl-protein, containing cobalt and zinc.
  • The enzyme, described from the bacterium Propionibacterium shermanii, is unique among the biotin-dependent enzymes in that it catalyzes carboxyl transfer between two organic molecules, utilizing two separate carboxyltransferase domains.
  • The enzyme is a very large complex, consisting of a hexameric central core of 12S subunits surrounded by six 5S subunit dimers, each connected to the central core by twelve 1.3S biotin carrier subunits.
Cross-references
BRENDA2.1.3.1
EC2PDB2.1.3.1
ExplorEnz2.1.3.1
KEGG Ligand Database for Enzyme Nomenclature2.1.3.1
IUBMB Enzyme Nomenclature2.1.3.1
MEDLINEFind literature relating to 2.1.3.1
MetaCyc2.1.3.1
Rhea expert-curated reactions2.1.3.1
UniProtKB/Swiss-Prot
Q8GBW6, 12S_PROFRQ70AC7, 5S_PROFRP02904, BCCP_PROFR

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