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ENZYME entry: EC 2.1.3.11

Accepted Name
N-succinylornithine carbamoyltransferase.
Alternative Name(s)
N-succinyl-L-ornithine transcarbamylase.
SOTCase.
Succinylornithine transcarbamylase.
Reaction catalysed
Carbamoyl phosphate + N(2)-succinyl-L-ornithine <=> phosphate + N-succinyl-L-citrulline
Comment(s)
  • Specific for N-succinyl-L-ornithine and cannot use either L-ornithine (see EC 2.1.3.3) or N-acetyl-L-ornithine (see EC 2.1.3.9) as substrate.
  • However, a single amino-acid substitution (Pro90Glu) is sufficient to switch the enzyme to one that uses N-acetyl-L-ornithine as substrate.
  • It is essential for de novo arginine biosynthesis in the obligate anaerobe Bacteroides fragilis, suggesting that this organism uses an alternative pathway for synthesizing arginine.
Cross-references
BRENDA2.1.3.11
EC2PDB2.1.3.11
ExplorEnz2.1.3.11
PRIAM enzyme-specific profiles2.1.3.11
KEGG Ligand Database for Enzyme Nomenclature2.1.3.11
IUBMB Enzyme Nomenclature2.1.3.11
IntEnz2.1.3.11
MEDLINEFind literature relating to 2.1.3.11
MetaCyc2.1.3.11
Rhea expert-curated reactions2.1.3.11
UniProtKB/Swiss-Prot
E1WKT5, SOTC_BACF6;  Q8A1E9, SOTC_BACTN;  

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