ENZYME

Home | Contact

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.1.3.11

Accepted Name
N-succinylornithine carbamoyltransferase.
Alternative Name(s)
N-succinyl-L-ornithine transcarbamylase.
SOTCase.
Succinylornithine transcarbamylase.
Reaction catalysed
Carbamoyl phosphate + N(2)-succinyl-L-ornithine <=> phosphate + N-succinyl-L-citrulline
Comment(s)
Specific for N-succinyl-L-ornithine and cannot use either L-ornithine (see EC 2.1.3.3) or N-acetyl-L-ornithine (see EC 2.1.3.9) as substrate. However, a single amino-acid substitution (Pro90Glu) is sufficient to switch the enzyme to one that uses N-acetyl-L-ornithine as substrate. It is essential for de novo arginine biosynthesis in the obligate anaerobe Bacteroides fragilis, suggesting that this organism uses an alternative pathway for synthesizing arginine.
Cross-references
BRENDA	2.1.3.11
EC2PDB	2.1.3.11
ExplorEnz	2.1.3.11
PRIAM enzyme-specific profiles	2.1.3.11
KEGG Ligand Database for Enzyme Nomenclature	2.1.3.11
IUBMB Enzyme Nomenclature	2.1.3.11
IntEnz	2.1.3.11
MEDLINE	Find literature relating to 2.1.3.11
MetaCyc	2.1.3.11