ENZYME entry: EC 2.1.3.11
Accepted Name |
N-succinylornithine carbamoyltransferase.
|
Alternative Name(s) |
N-succinyl-L-ornithine transcarbamylase. |
SOTCase. |
succinylornithine transcarbamylase. |
Reaction catalysed |
carbamoyl phosphate + N(2)-succinyl-L-ornithine <=> H(+) + N(2)-succinyl-L-citrulline + phosphate |
Comment(s) |
- Specific for N-succinyl-L-ornithine and cannot use either L-ornithine
(see EC 2.1.3.3) or N-acetyl-L-ornithine (see EC 2.1.3.9) as
substrate.
- However, a single amino-acid substitution (Pro90Glu) is sufficient to
switch the enzyme to one that uses N-acetyl-L-ornithine as substrate.
- It is essential for de novo arginine biosynthesis in the obligate
anaerobe Bacteroides fragilis, suggesting that this organism uses an
alternative pathway for synthesizing arginine.
|
Cross-references |
BRENDA | 2.1.3.11 |
EC2PDB | 2.1.3.11 |
ExplorEnz | 2.1.3.11 |
PRIAM enzyme-specific profiles | 2.1.3.11 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.3.11 |
IUBMB Enzyme Nomenclature | 2.1.3.11 |
IntEnz | 2.1.3.11 |
MEDLINE | Find literature relating to 2.1.3.11 |
MetaCyc | 2.1.3.11 |
Rhea expert-curated reactions | 2.1.3.11 |
UniProtKB/Swiss-Prot |
|
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