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ENZYME entry: EC 2.2.1.1

Accepted Name
Transketolase.
Alternative Name(s)
Glycoaldehyde transferase.
Reaction catalysed
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-ribose 5-phosphate + D-xylulose 5-phosphate
Cofactor(s)
Thiamine diphosphate.
Comment(s)
  • Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO(2) and R-CHOH-CO-CH(2)OH.
  • The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.
Cross-references
PROSITEPDOC00635
BRENDA2.2.1.1
EC2PDB2.2.1.1
ExplorEnz2.2.1.1
PRIAM enzyme-specific profiles2.2.1.1
KEGG Ligand Database for Enzyme Nomenclature2.2.1.1
IUBMB Enzyme Nomenclature2.2.1.1
IntEnz2.2.1.1
MEDLINEFind literature relating to 2.2.1.1
MetaCyc2.2.1.1
UniProtKB/Swiss-Prot
Q5E7R1, TKT1_ALIF1;  O94039, TKT1_CANAX;  P27302, TKT1_ECOLI;  
Q12630, TKT1_KLULA;  P57927, TKT1_PASMU;  Q9KUP2, TKT1_VIBCH;  
Q87LK8, TKT1_VIBPA;  Q8DCA2, TKT1_VIBVU;  Q7MHK7, TKT1_VIBVY;  
P51010, TKT1_XANFL;  P23254, TKT1_YEAST;  Q5DZP0, TKT2_ALIF1;  
P33570, TKT2_ECOLI;  P57958, TKT2_PASMU;  Q9KLW7, TKT2_VIBCH;  
Q87GY4, TKT2_VIBPA;  Q8D6H8, TKT2_VIBVU;  Q7MDD4, TKT2_VIBVY;  
Q60103, TKT2_XANFL;  P33315, TKT2_YEAST;  Q42677, TKT7_CRAPL;  
Q42675, TKTA_CRAPL;  Q8RWV0, TKTC1_ARATH;  F4IW47, TKTC2_ARATH;  
Q42676, TKTC_CRAPL;  P21725, TKTC_CUPNH;  Q7SIC9, TKTC_MAIZE;  
Q58092, TKTC_METJA;  Q43848, TKTC_SOLTU;  O20250, TKTC_SPIOL;  
Q2NL26, TKTL1_BOVIN;  P51854, TKTL1_HUMAN;  Q4R6M8, TKTL1_MACFA;  
Q99MX0, TKTL1_MOUSE;  Q2NKZ4, TKTL2_BOVIN;  Q9H0I9, TKTL2_HUMAN;  
Q9D4D4, TKTL2_MOUSE;  Q58094, TKTN_METJA;  P21726, TKTP_CUPNH;  
O67642, TKT_AQUAE;  Q9KAD7, TKT_BACHD;  P45694, TKT_BACSU;  
Q6B855, TKT_BOVIN;  P57195, TKT_BUCAI;  Q8KA26, TKT_BUCAP;  
Q89AY2, TKT_BUCBP;  Q556J0, TKT_DICDI;  A0A0I9QGZ2, TKT_GEOSE;  
P43757, TKT_HAEIN;  P29401, TKT_HUMAN;  Q60HC7, TKT_MACFA;  
P40142, TKT_MOUSE;  P59956, TKT_MYCBO;  P47312, TKT_MYCGE;  
P46708, TKT_MYCLE;  P75611, TKT_MYCPN;  P9WG24, TKT_MYCTO;  
P9WG25, TKT_MYCTU;  Q8YRU9, TKT_NOSS1;  Q5R1W6, TKT_PANTR;  
A6YB01, TKT_PHYPO;  P34736, TKT_PICST;  Q5R4C1, TKT_PONAB;  
P84540, TKT_POPEU;  P50137, TKT_RAT;  P58333, TKT_RHIME;  
P0CZ16, TKT_RHOCA;  D5AV94, TKT_RHOCB;  P29277, TKT_RHOSH;  
Q9URM2, TKT_SCHPO;  P56900, TKT_SINMW;  Q5HG77, TKT_STAAC;  
P66962, TKT_STAAM;  P99161, TKT_STAAN;  Q6GH64, TKT_STAAR;  
Q6G9L6, TKT_STAAS;  P66963, TKT_STAAW;  Q5HPJ9, TKT_STAEQ;  
Q8CPC7, TKT_STAES;  Q5XAK5, TKT_STRP6;  Q8NZX4, TKT_STRP8;  
P22976, TKT_STRPN;  O83571, TKT_TREPA;  

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