ENZYME entry: EC 2.2.1.10
| Accepted Name |
|---|
| 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase.
|
| Alternative Name(s) |
|---|
| ADH synthase. |
| Reaction catalysed |
|---|
| L-aspartate 4-semialdehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate <=> 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate + 2,3-dioxopropylaldehyde phosphate |
| Comment(s) |
|---|
- The enzyme plays a key role in an alternative pathway of the
biosynthesis of 3-dehydroquinate (DHQ), which is involved in the
canonical pathway for the biosynthesis of aromatic amino acids.
- The enzyme can also catalyze the cleavage of fructose-1,6-
bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone
phosphate.
- Formerly EC 4.1.2.n5.
|
| Cross-references |
|---|
| BRENDA | 2.2.1.10 |
| EC2PDB | 2.2.1.10 |
| ExplorEnz | 2.2.1.10 |
| PRIAM enzyme-specific profiles | 2.2.1.10 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.2.1.10 |
| IUBMB Enzyme Nomenclature | 2.2.1.10 |
| IntEnz | 2.2.1.10 |
| MEDLINE | Find literature relating to 2.2.1.10 |
| MetaCyc | 2.2.1.10 |
| UniProtKB/Swiss-Prot |
| O30009, ADHS1_ARCFU; | O30128, ADHS2_ARCFU; | O67506, ADHS_AQUAE; |
| Q9HSB8, ADHS_HALSA; | A6UTT2, ADHS_META3; | Q57843, ADHS_METJA; |
| A4FYB3, ADHS_METM5; | A9A799, ADHS_METM6; | A6VJZ0, ADHS_METM7; |
| Q6LZE3, ADHS_METMP; | O26679, ADHS_METTH; | A6USC8, ADHS_METVS; |
|
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