ENZYME entry: EC 2.2.1.10
Accepted Name |
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase.
|
Alternative Name(s) |
ADH synthase. |
Reaction catalysed |
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde <=> 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate |
Comment(s) |
- The enzyme plays a key role in an alternative pathway of the
biosynthesis of 3-dehydroquinate (DHQ), which is involved in the
canonical pathway for the biosynthesis of aromatic amino acids.
- The enzyme can also catalyze the cleavage of fructose-1,6-
bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone
phosphate.
- Formerly EC 4.1.2.n5.
|
Cross-references |
BRENDA | 2.2.1.10 |
EC2PDB | 2.2.1.10 |
ExplorEnz | 2.2.1.10 |
PRIAM enzyme-specific profiles | 2.2.1.10 |
KEGG Ligand Database for Enzyme Nomenclature | 2.2.1.10 |
IUBMB Enzyme Nomenclature | 2.2.1.10 |
IntEnz | 2.2.1.10 |
MEDLINE | Find literature relating to 2.2.1.10 |
MetaCyc | 2.2.1.10 |
Rhea expert-curated reactions | 2.2.1.10 |
UniProtKB/Swiss-Prot |
O30009, ADHS1_ARCFU; | O30128, ADHS2_ARCFU; | O67506, ADHS_AQUAE; |
Q9HSB8, ADHS_HALSA; | A6UTT2, ADHS_META3; | Q57843, ADHS_METJA; |
A4FYB3, ADHS_METM5; | A9A799, ADHS_METM6; | A6VJZ0, ADHS_METM7; |
Q6LZE3, ADHS_METMP; | O26679, ADHS_METTH; | A6USC8, ADHS_METVS; |
|
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