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ENZYME

ENZYME entry: EC 2.2.1.10

PURL: https://purl.expasy.org/enzyme/EC/2.2.1.10
Accepted Name
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Alternative Name(s)
ADH synthase
Reaction catalysed
1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-lyxo-hept-6-ulosonate
Comment(s)
  • The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
  • The enzyme can also catalyze the cleavage of fructose-1,6- bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate.
  • Formerly EC 4.1.2.n5.
Cross-references
BRENDA2.2.1.10
EC2PDB2.2.1.10
ExplorEnz2.2.1.10
KEGG Ligand Database for Enzyme Nomenclature2.2.1.10
IUBMB Enzyme Nomenclature2.2.1.10
MEDLINEFind literature relating to 2.2.1.10
MetaCyc2.2.1.10
Rhea expert-curated reactions2.2.1.10
UniProtKB/Swiss-Prot
O30009, ADHS1_ARCFUO30128, ADHS2_ARCFUO67506, ADHS_AQUAE
Q9HSB8, ADHS_HALSAA6UTT2, ADHS_META3Q57843, ADHS_METJA
A4FYB3, ADHS_METM5A9A799, ADHS_METM6A6VJZ0, ADHS_METM7
Q6LZE3, ADHS_METMPO26679, ADHS_METTHA6USC8, ADHS_METVS

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-