ENZYME entry: EC 2.2.1.12

Accepted Name
3-acetyloctanal synthase.
Reaction catalysed
Pyruvate + (E)-oct-2-enal <=> (S)-3-acetyloctanal + CO(2)
Cofactor(s)
Thiamine diphosphate.
Comment(s)
  • The enzyme, characterized from the bacterium Serratia marcescens, participates in the biosynthesis of the antibiotic prodigiosin.
  • The enzyme decarboxylates pyruvate, followed by attack of the resulting two-carbon fragment on (E)-oct-2-enal, resulting in a Stetter reaction.
  • In vitro the enzyme can act on a number of alpha,beta-unsaturated carbonyl compounds, including aldehydes and ketones, and can catalyze both 1-2 and 1-4 carboligations depending on the substrate.
Cross-references
BRENDA2.2.1.12
EC2PDB2.2.1.12
ExplorEnz2.2.1.12
PRIAM enzyme-specific profiles2.2.1.12
KEGG Ligand Database for Enzyme Nomenclature2.2.1.12
IUBMB Enzyme Nomenclature2.2.1.12
IntEnz2.2.1.12
MEDLINEFind literature relating to 2.2.1.12
MetaCyc2.2.1.12
UniProtKB/Swiss-Prot
Q5W251, PIGD_SERMA;  Q5W268, PIGD_SERS3;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-