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ENZYME

ENZYME entry: EC 2.2.1.5

PURL: https://purl.expasy.org/enzyme/EC/2.2.1.5
Accepted Name
2-hydroxy-3-oxoadipate synthase
Alternative Name(s)
2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating)
2-hydroxy-3-oxoadipate synthetase
alpha-ketoglutaric-glyoxylic carboligase
oxoglutarate: glyoxylate carboligase
Reaction catalysed
glyoxylate + 2-oxoglutarate + H(+) = 2-hydroxy-3-oxoadipate + CO2
Comment(s)
  • The product decarboxylates to 5-hydroxy-4-oxopentanoate.
  • The enzyme can decarboxylate 2-oxoglutarate.
  • Acetaldehyde can replace glyoxylate.
  • Formerly EC 4.1.3.15.
Cross-references
BRENDA2.2.1.5
EC2PDB2.2.1.5
ExplorEnz2.2.1.5
KEGG Ligand Database for Enzyme Nomenclature2.2.1.5
IUBMB Enzyme Nomenclature2.2.1.5
MEDLINEFind literature relating to 2.2.1.5
MetaCyc2.2.1.5
Rhea expert-curated reactions2.2.1.5
UniProtKB/Swiss-Prot
Q7U0A6, KGD_MYCBOA1KI36, KGD_MYCBPQ9CC97, KGD_MYCLE
Q73WX4, KGD_MYCPAA0R2B1, KGD_MYCS2A3Q3N5, KGD_MYCSJ
A1UK81, KGD_MYCSKQ1B4V6, KGD_MYCSSA5U1U6, KGD_MYCTA
P9WIS4, KGD_MYCTOP9WIS5, KGD_MYCTUA0PVU7, KGD_MYCUA
A1TDK2, KGD_MYCVP

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-