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ENZYME entry: EC 2.2.1.5

Accepted Name
2-hydroxy-3-oxoadipate synthase.
Alternative Name(s)
2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating).
2-hydroxy-3-oxoadipate synthetase.
Alpha-ketoglutaric-glyoxylic carboligase.
Oxoglutarate: glyoxylate carboligase.
Reaction catalysed
2-oxoglutarate + glyoxylate <=> 2-hydroxy-3-oxoadipate + CO(2)
Cofactor(s)
Thiamine diphosphate.
Comment(s)
  • The product decarboxylates to 5-hydroxy-4-oxopentanoate.
  • The enzyme can decarboxylate 2-oxoglutarate.
  • Acetaldehyde can replace glyoxylate.
  • Formerly EC 4.1.3.15.
Cross-references
BRENDA2.2.1.5
EC2PDB2.2.1.5
ExplorEnz2.2.1.5
PRIAM enzyme-specific profiles2.2.1.5
KEGG Ligand Database for Enzyme Nomenclature2.2.1.5
IUBMB Enzyme Nomenclature2.2.1.5
IntEnz2.2.1.5
MEDLINEFind literature relating to 2.2.1.5
MetaCyc2.2.1.5
Rhea expert-curated reactions2.2.1.5
UniProtKB/Swiss-Prot
Q7U0A6, KGD_MYCBO;  A1KI36, KGD_MYCBP;  Q9CC97, KGD_MYCLE;  
Q73WX4, KGD_MYCPA;  A0R2B1, KGD_MYCS2;  A3Q3N5, KGD_MYCSJ;  
A1UK81, KGD_MYCSK;  Q1B4V6, KGD_MYCSS;  A5U1U6, KGD_MYCTA;  
P9WIS4, KGD_MYCTO;  P9WIS5, KGD_MYCTU;  A0PVU7, KGD_MYCUA;  
A1TDK2, KGD_MYCVP;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.1.-
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