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ENZYME

ENZYME entry: EC 2.2.1.6

PURL: https://purl.expasy.org/enzyme/EC/2.2.1.6
Accepted Name
acetolactate synthase
Alternative Name(s)
acetohydroxyacid synthase
acetohydroxy acid synthetase
acetolactate pyruvate-lyase (carboxylating)
acetolactic synthetase
alpha-acetohydroxyacid synthase
alpha-acetohydroxy acid synthetase
alpha-acetolactate synthase
alpha-acetolactate synthetase
Reaction catalysed
2 pyruvate + H(+) = (2S)-2-acetolactate + CO2
Comment(s)
  • The reaction shown is in the pathway of biosynthesis of valine.
  • The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.
  • Formerly EC 4.1.3.18.
Cross-references
BRENDA2.2.1.6
EC2PDB2.2.1.6
ExplorEnz2.2.1.6
KEGG Ligand Database for Enzyme Nomenclature2.2.1.6
IUBMB Enzyme Nomenclature2.2.1.6
MEDLINEFind literature relating to 2.2.1.6
MetaCyc2.2.1.6
Rhea expert-curated reactions2.2.1.6
UniProtKB/Swiss-Prot
A0A2I2F2I5, CFOL_ASPCNP27818, ILVB1_BRANAQ41768, ILVB1_MAIZE
P9WG40, ILVB1_MYCTOP9WG41, ILVB1_MYCTUQ6K2E8, ILVB1_ORYSJ
P09342, ILVB1_TOBACP14874, ILVB2_BRANAQ41769, ILVB2_MAIZE
O06335, ILVB2_MYCTUQ7XKQ8, ILVB2_ORYSJP09114, ILVB2_TOBAC
P27819, ILVB3_BRANAP17597, ILVB_ARATHP27868, ILVB_ARTPT
P37251, ILVB_BACSUP42463, ILVB_CORGLQ6SSJ3, ILVB_CRYNH
Q5KPJ5, ILVB_CRYNJO19929, ILVB_CYACAP08142, ILVB_ECOLI
O78518, ILVB_GUITHQ09129, ILVB_KLEAEP27696, ILVB_KLEPN
Q02137, ILVB_LACLAO08353, ILVB_METAOQ57725, ILVB_METJA
Q59498, ILVB_MYCAVP0A623, ILVB_MYCBOO33112, ILVB_MYCLE
Q7U5G1, ILVB_PARMWP69683, ILVB_PORPUP69684, ILVB_PORUM
Q1XDF6, ILVB_PYRYEQ04524, ILVB_RAOTEP36620, ILVB_SCHPO
P07342, ILVB_YEASTP0DP90, ILVG_ECOLIP66947, ILVG_MYCBO
P9WG38, ILVG_MYCTOP9WG39, ILVG_MYCTUO67703, ILVH_AQUAE
O28555, ILVH_ARCFUP37252, ILVH_BACSUP57320, ILVH_BUCAI
O85294, ILVH_BUCAPQ89AP8, ILVH_BUCBPQ9TLY1, ILVH_CYACA
P00894, ILVH_ECOLIQ9MS98, ILVH_GALSUO78451, ILVH_GUITH
P45260, ILVH_HAEINQ02140, ILVH_LACLAQ57625, ILVH_METJA
O27492, ILVH_METTHQ59499, ILVH_MYCAVP65162, ILVH_MYCBO
O33113, ILVH_MYCLEA0QUX7, ILVH_MYCS2P9WKJ2, ILVH_MYCTO
P9WKJ3, ILVH_MYCTUP51230, ILVH_PORPUQ1XDQ7, ILVH_PYRYE
P21622, ILVH_SALTYQ55141, ILVH_SYNY3P57321, ILVI_BUCAI
O85293, ILVI_BUCAPQ89AP7, ILVI_BUCBPQ9RQ65, ILVI_BUCSC
P00893, ILVI_ECOLIP45261, ILVI_HAEINP40811, ILVI_SALTY
P0ADG2, ILVM_ECOL6P0ADG1, ILVM_ECOLIP0ADG3, ILVM_SHIFL
P0ADG0, ILVN_ECO57P0ADF9, ILVN_ECOL6P0ADF8, ILVN_ECOLI
Q04789, ILVX_BACSUO53554, ILVX_MYCTU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-