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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.2.1.6

Accepted Name
Acetolactate synthase.
Alternative Name(s)
Acetohydroxy acid synthetase.
Acetohydroxyacid synthase.
Acetolactate pyruvate-lyase (carboxylating).
Acetolactic synthetase.
Alpha-acetohydroxy acid synthetase.
Alpha-acetohydroxyacid synthase.
Alpha-acetolactate synthase.
Alpha-acetolactate synthetase.
Reaction catalysed
2 pyruvate <=> 2-acetolactate + CO(2)
Cofactor(s)
Thiamine diphosphate.
Comment(s)
  • The reaction shown is in the pathway of biosynthesis of valine.
  • The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.
  • Formerly EC 4.1.3.18.
Cross-references
PROSITEPDOC00166
BRENDA2.2.1.6
EC2PDB2.2.1.6
ExplorEnz2.2.1.6
PRIAM enzyme-specific profiles2.2.1.6
KEGG Ligand Database for Enzyme Nomenclature2.2.1.6
IUBMB Enzyme Nomenclature2.2.1.6
IntEnz2.2.1.6
MEDLINEFind literature relating to 2.2.1.6
MetaCyc2.2.1.6
UniProtKB/Swiss-Prot
P27818, ILVB1_BRANA;  Q41768, ILVB1_MAIZE;  P9WG40, ILVB1_MYCTO;  
P9WG41, ILVB1_MYCTU;  Q6K2E8, ILVB1_ORYSJ;  P09342, ILVB1_TOBAC;  
P14874, ILVB2_BRANA;  Q41769, ILVB2_MAIZE;  O06335, ILVB2_MYCTU;  
Q7XKQ8, ILVB2_ORYSJ;  P09114, ILVB2_TOBAC;  P27819, ILVB3_BRANA;  
P17597, ILVB_ARATH;  P27868, ILVB_ARTPT;  P37251, ILVB_BACSU;  
P42463, ILVB_CORGL;  Q6SSJ3, ILVB_CRYNH;  Q5KPJ5, ILVB_CRYNJ;  
O19929, ILVB_CYACA;  P08142, ILVB_ECOLI;  O78518, ILVB_GUITH;  
Q09129, ILVB_KLEAE;  P27696, ILVB_KLEPN;  Q02137, ILVB_LACLA;  
O08353, ILVB_METAO;  Q57725, ILVB_METJA;  Q59498, ILVB_MYCAV;  
P0A623, ILVB_MYCBO;  O33112, ILVB_MYCLE;  P69683, ILVB_PORPU;  
P69684, ILVB_PORUM;  Q1XDF6, ILVB_PYRYE;  Q04524, ILVB_RAOTE;  
P36620, ILVB_SCHPO;  Q7U5G1, ILVB_SYNPX;  P07342, ILVB_YEAST;  
P0DP90, ILVG_ECOLI;  P66947, ILVG_MYCBO;  P9WG38, ILVG_MYCTO;  
P9WG39, ILVG_MYCTU;  O67703, ILVH_AQUAE;  O28555, ILVH_ARCFU;  
P37252, ILVH_BACSU;  P57320, ILVH_BUCAI;  O85294, ILVH_BUCAP;  
Q89AP8, ILVH_BUCBP;  Q9TLY1, ILVH_CYACA;  P00894, ILVH_ECOLI;  
Q9MS98, ILVH_GALSU;  O78451, ILVH_GUITH;  P45260, ILVH_HAEIN;  
Q02140, ILVH_LACLA;  Q57625, ILVH_METJA;  O27492, ILVH_METTH;  
Q59499, ILVH_MYCAV;  P65162, ILVH_MYCBO;  O33113, ILVH_MYCLE;  
A0QUX7, ILVH_MYCS2;  P9WKJ2, ILVH_MYCTO;  P9WKJ3, ILVH_MYCTU;  
P51230, ILVH_PORPU;  Q1XDQ7, ILVH_PYRYE;  P21622, ILVH_SALTY;  
Q55141, ILVH_SYNY3;  P57321, ILVI_BUCAI;  O85293, ILVI_BUCAP;  
Q89AP7, ILVI_BUCBP;  Q9RQ65, ILVI_BUCSC;  P00893, ILVI_ECOLI;  
P45261, ILVI_HAEIN;  P40811, ILVI_SALTY;  P0ADG2, ILVM_ECOL6;  
P0ADG1, ILVM_ECOLI;  P0ADG3, ILVM_SHIFL;  P0ADG0, ILVN_ECO57;  
P0ADF9, ILVN_ECOL6;  P0ADF8, ILVN_ECOLI;  Q04789, ILVX_BACSU;  
O53554, ILVX_MYCTU;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-