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ENZYME

ENZYME entry: EC 2.2.1.6

PURL: https://purl.expasy.org/enzyme/EC/2.2.1.6
Accepted Name
acetolactate synthase
Alternative Name(s)
acetohydroxyacid synthase
acetohydroxy acid synthetase
acetolactate pyruvate-lyase (carboxylating)
acetolactic synthetase
alpha-acetohydroxyacid synthase
alpha-acetohydroxy acid synthetase
alpha-acetolactate synthase
alpha-acetolactate synthetase
Reaction catalysed
2 pyruvate + H(+) = (2S)-2-acetolactate + CO2
Comment(s)
  • The reaction shown is in the pathway of biosynthesis of valine.
  • The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine.
  • Formerly EC 4.1.3.18.
Cross-references
Rhea expert-curated reactions2.2.1.6
ExplorEnz2.2.1.6
IUBMB Enzyme Nomenclature2.2.1.6
UniProtKB/Swiss-Prot
A0A2I2F2I5, CFOL_ASPCNG2XCJ0, ILV2_VERDVP27818, ILVB1_BRANA
Q41768, ILVB1_MAIZEP9WG40, ILVB1_MYCTOP9WG41, ILVB1_MYCTU
Q6K2E8, ILVB1_ORYSJP09342, ILVB1_TOBACP14874, ILVB2_BRANA
Q41769, ILVB2_MAIZEO06335, ILVB2_MYCTUQ7XKQ8, ILVB2_ORYSJ
P09114, ILVB2_TOBACP27819, ILVB3_BRANAP17597, ILVB_ARATH
P37251, ILVB_BACSUP42463, ILVB_CORGLQ5KPJ5, ILVB_CRYD1
Q6SSJ3, ILVB_CRYN9O19929, ILVB_CYACAP08142, ILVB_ECOLI
O78518, ILVB_GUITHQ09129, ILVB_KLEAEP27696, ILVB_KLEPN
Q04524, ILVB_KLETEQ02137, ILVB_LACLAP27868, ILVB_LIMPL
O08353, ILVB_METAOQ57725, ILVB_METJAQ59498, ILVB_MYCAV
P0A623, ILVB_MYCBOO33112, ILVB_MYCLEQ7U5G1, ILVB_PARMW
P69683, ILVB_PORPUP69684, ILVB_PORUMQ1XDF6, ILVB_PYRYE
P36620, ILVB_SCHPOP07342, ILVB_YEASTP0DP90, ILVG_ECOLI
P66947, ILVG_MYCBOP9WG38, ILVG_MYCTOP9WG39, ILVG_MYCTU
O67703, ILVH_AQUAEO28555, ILVH_ARCFUP37252, ILVH_BACSU
P57320, ILVH_BUCAIO85294, ILVH_BUCAPQ89AP8, ILVH_BUCBP
Q9TLY1, ILVH_CYACAP00894, ILVH_ECOLIQ9MS98, ILVH_GALSU
O78451, ILVH_GUITHP45260, ILVH_HAEINQ02140, ILVH_LACLA
Q57625, ILVH_METJAO27492, ILVH_METTHQ59499, ILVH_MYCAV
P65162, ILVH_MYCBOO33113, ILVH_MYCLEA0QUX7, ILVH_MYCS2
P9WKJ2, ILVH_MYCTOP9WKJ3, ILVH_MYCTUP51230, ILVH_PORPU
Q1XDQ7, ILVH_PYRYEP21622, ILVH_SALTYQ55141, ILVH_SYNY3
P57321, ILVI_BUCAIO85293, ILVI_BUCAPQ89AP7, ILVI_BUCBP
Q9RQ65, ILVI_BUCSCP00893, ILVI_ECOLIP45261, ILVI_HAEIN
P40811, ILVI_SALTYP0ADG2, ILVM_ECOL6P0ADG1, ILVM_ECOLI
P0ADG3, ILVM_SHIFLP0ADG0, ILVN_ECO57P0ADF9, ILVN_ECOL6
P0ADF8, ILVN_ECOLIQ04789, ILVX_BACSUO53554, ILVX_MYCTU
BRENDA2.2.1.6
MetaCyc2.2.1.6
KEGG Ligand Database for Enzyme Nomenclature2.2.1.6
MEDLINEFind literature relating to 2.2.1.6

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-