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ENZYME

ENZYME entry: EC 2.2.1.7

Accepted Name
1-deoxy-D-xylulose-5-phosphate synthase
Alternative Name(s)
1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating)
1-deoxyxylulose-5-phosphate synthase
DXP-synthase
Reaction catalysed
D-glyceraldehyde 3-phosphate + H(+) + pyruvate <=> 1-deoxy-D-xylulose 5-phosphate + CO2
Comment(s)
  • The enzyme forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.
  • Formerly EC 4.1.3.37.
Cross-references
BRENDA2.2.1.7
EC2PDB2.2.1.7
ExplorEnz2.2.1.7
PRIAM enzyme-specific profiles2.2.1.7
KEGG Ligand Database for Enzyme Nomenclature2.2.1.7
IUBMB Enzyme Nomenclature2.2.1.7
IntEnz2.2.1.7
MEDLINEFind literature relating to 2.2.1.7
MetaCyc2.2.1.7
Rhea expert-curated reactions2.2.1.7
UniProtKB/Swiss-Prot
Q3J1A8, DXS1_CERS4Q39UB1, DXS1_GEOMGQ74FC3, DXS1_GEOSL
Q28WA7, DXS1_JANSCQ9F1V2, DXS1_KITGRO22567, DXS1_ORYSJ
Q2RYD6, DXS1_RHORTQ16DV7, DXS1_ROSDOQ82ML4, DXS1_STRAW
Q9X7W3, DXS1_STRCOQ5NN52, DXS1_ZYMMOQ3IYR6, DXS2_CERS4
Q39RT4, DXS2_GEOMGQ74CB0, DXS2_GEOSLQ28W25, DXS2_JANSC
Q8VUR8, DXS2_KITGRQ6YU51, DXS2_ORYSJQ2RR29, DXS2_RHORT
Q16CP0, DXS2_ROSDOQ82KW8, DXS2_STRAWQ8CJP7, DXS2_STRCO
Q5NM38, DXS2_ZYMMOB0C8J3, DXS_ACAM1A1TNR1, DXS_ACIAC
Q6F7N5, DXS_ACIADB0VQB8, DXS_ACIBSB0V710, DXS_ACIBY
C1F3C4, DXS_ACIC5B9MEU8, DXS_ACIETA1W4U9, DXS_ACISJ
A3MYS9, DXS_ACTP2B3H050, DXS_ACTP7B0BSL0, DXS_ACTPJ
A0KNF9, DXS_AERHHA4SJP9, DXS_AERS4Q8UHD7, DXS_AGRFC
B9JAL7, DXS_AGRRKB9JSL2, DXS_AGRVSQ21UG7, DXS_ALBFT
Q0VMI4, DXS_ALCBSA8EWN0, DXS_ALIB4Q5E6Z0, DXS_ALIF1
B5FBG6, DXS_ALIFMB6EIA7, DXS_ALISLQ5WF63, DXS_ALKCK
Q0A8V7, DXS_ALKEHA8MFI7, DXS_ALKOOB4RVY8, DXS_ALTMD
B8JFY1, DXS_ANAD2Q2IPZ2, DXS_ANADEA7H9E8, DXS_ANADF
B4UHF5, DXS_ANASKO67036, DXS_AQUAEQ38854, DXS_ARATH
Q5P228, DXS_AROAEA0JVG9, DXS_ARTS2A8IBS1, DXS_AZOC5
B6YRV5, DXS_AZOPCA1K4R0, DXS_AZOSBC3P7V6, DXS_BACAA
C3LJV1, DXS_BACACQ81M54, DXS_BACANB7JM28, DXS_BACC0
Q731B7, DXS_BACC1B7IXG8, DXS_BACC2B7HB48, DXS_BACC4
B7HNU0, DXS_BACC7A7GSJ5, DXS_BACCNQ818R9, DXS_BACCR
Q635A7, DXS_BACCZQ5LH44, DXS_BACFNQ64Y02, DXS_BACFR
Q6HDY8, DXS_BACHKQ65HJ2, DXS_BACLDA9VGD1, DXS_BACMK
A8FF11, DXS_BACP2P54523, DXS_BACSUQ8A0C2, DXS_BACTN
A7Z6J5, DXS_BACVZA1URW6, DXS_BARBKQ6G4D1, DXS_BARHE
Q6G0D4, DXS_BARQUA9IQP2, DXS_BART1Q1LTI9, DXS_BAUCH
B2IDK3, DXS_BEII9Q7VRH9, DXS_BLOFLQ493G7, DXS_BLOPB
Q2KZ15, DXS_BORA1Q7WL37, DXS_BORBRQ7W7Q0, DXS_BORPA
A9ITB0, DXS_BORPDQ7VV87, DXS_BORPEQ89RW1, DXS_BRADU
A5EEQ0, DXS_BRASBA4YQ36, DXS_BRASOC0ZC10, DXS_BREBN
B2S9T6, DXS_BRUA1Q2YMF0, DXS_BRUA2A6WWC4, DXS_BRUA4
Q57ET1, DXS_BRUABA9M8W0, DXS_BRUC2C0RHE3, DXS_BRUMB
Q8YFM2, DXS_BRUMEA5VP09, DXS_BRUO2B0CKC0, DXS_BRUSI
Q8G292, DXS_BRUSUB8D9P1, DXS_BUCA5P57536, DXS_BUCAI
Q8K9A1, DXS_BUCAPB8D7Z3, DXS_BUCATB1Z1G2, DXS_BURA4
A0AYZ0, DXS_BURCHB4EN29, DXS_BURCJQ0BAL8, DXS_BURCM
Q393P4, DXS_BURL3Q62DU1, DXS_BURMAB1K3S9, DXS_BURO0
Q1BLY7, DXS_BURO1A3P7W4, DXS_BURP0Q3JKA3, DXS_BURP1
A3NMF6, DXS_BURP6Q63JF4, DXS_BURPSQ2T7N5, DXS_BURTA
Q8RAC5, DXS_CALS4A0RMN5, DXS_CAMFFA7I2V7, DXS_CAMHC
A8FKB0, DXS_CAMJ8A7H552, DXS_CAMJDQ9PIH8, DXS_CAMJE
A1VY40, DXS_CAMJJQ5HWF0, DXS_CAMJRO78328, DXS_CAPAN
Q3AAN0, DXS_CARHZB0T3X7, DXS_CAUSKQ9A6M5, DXS_CAUVC
B8GXC4, DXS_CAUVNB3PF22, DXS_CELJUQ11KE0, DXS_CHESB
Q5L6H4, DXS_CHLABQ823V1, DXS_CHLCVQ253R7, DXS_CHLFF
Q3B5P3, DXS_CHLL3Q9PK62, DXS_CHLMUA4SDG1, DXS_CHLPM
Q9Z6J9, DXS_CHLPNB0B7P9, DXS_CHLT2Q3KM28, DXS_CHLTA
B0BBW4, DXS_CHLTBQ8KFI9, DXS_CHLTEO84335, DXS_CHLTR
Q1R1E5, DXS_CHRSDQ7NUK5, DXS_CHRVOA8AK34, DXS_CITK8
B0RC26, DXS_CLAMSQ97HD5, DXS_CLOABA6LU48, DXS_CLOB8
B2V4R3, DXS_CLOBAB2TRM5, DXS_CLOBBQ18B68, DXS_CLOD6
B9E104, DXS_CLOK1A5N7J2, DXS_CLOK5A0Q0A4, DXS_CLONN
Q0TPD8, DXS_CLOP1Q8XJE1, DXS_CLOPEQ0SS05, DXS_CLOPS
Q894H0, DXS_CLOTEQ487D3, DXS_COLP3Q6NGV3, DXS_CORDI
Q8FPI2, DXS_COREFA4QEQ9, DXS_CORGBQ8NPB2, DXS_CORGL
Q4JVB5, DXS_CORJKB1WWM7, DXS_CROS5A7MFG0, DXS_CROS8
Q1LK34, DXS_CUPMCQ0K860, DXS_CUPNHQ474C2, DXS_CUPPJ
B3R5H4, DXS_CUPTRQ6A8V3, DXS_CUTAKB8HWL8, DXS_CYAP4
Q11NY7, DXS_CYTH3Q47BJ0, DXS_DECARQ3Z8G9, DXS_DEHM1
A5FRB9, DXS_DEHMBQ3ZXC2, DXS_DEHMCQ1IZP0, DXS_DEIGD
Q9RUB5, DXS_DEIRAB1I3J6, DXS_DESAPB8FQ45, DXS_DESHD
Q24V05, DXS_DESHYQ6AJQ1, DXS_DESPSQ72CD3, DXS_DESVH
A1VE69, DXS_DESVVB5YE06, DXS_DICT6B8E247, DXS_DICTD
A7ZIH3, DXS_ECO24B7UJP3, DXS_ECO27B7MD78, DXS_ECO45
B7L654, DXS_ECO55Q8XE76, DXS_ECO57B5Z3S5, DXS_ECO5E
B7NJ77, DXS_ECO7IB7MQD5, DXS_ECO81B7M3Q9, DXS_ECO8A
C4ZTH7, DXS_ECOBWB1XF08, DXS_ECODHA7ZX72, DXS_ECOHS
A1A890, DXS_ECOK1Q0TKM1, DXS_ECOL5Q8FKB9, DXS_ECOL6
B1J029, DXS_ECOLCP77488, DXS_ECOLIB7N8X3, DXS_ECOLU
B6HZM1, DXS_ECOSEB1LJH0, DXS_ECOSMQ1RFC0, DXS_ECOUT
C5BCH9, DXS_EDWI9A4W791, DXS_ENT38B2VHS3, DXS_ERWT9
Q2N6U5, DXS_ERYLHB7LMG7, DXS_ESCF3B1YLQ5, DXS_EXIS2
Q2JDD9, DXS_FRACCB0U0B3, DXS_FRAP2A8L0K9, DXS_FRASN
Q14HJ1, DXS_FRAT1A7NCA4, DXS_FRATFQ2A3D3, DXS_FRATH
B2SGK5, DXS_FRATMA0Q6B9, DXS_FRATNQ0BLU9, DXS_FRATO
Q5NG39, DXS_FRATTA4IXW5, DXS_FRATWQ8R639, DXS_FUSNN
Q75TB7, DXS_GEOKAC5D467, DXS_GEOSWA4IQR7, DXS_GEOTN
B8F3A4, DXS_GLAP5B7KAF7, DXS_GLOC7Q7NP63, DXS_GLOVI
Q5FUB1, DXS_GLUOXQ7VNP7, DXS_HAEDUQ4QKG6, DXS_HAEI8
A5UC51, DXS_HAEIEA5UEV6, DXS_HAEIGP45205, DXS_HAEIN
Q0I3G1, DXS_HAES1Q2SA08, DXS_HAHCHQ9K971, DXS_HALH5
B8D2I3, DXS_HALOHC4K6M7, DXS_HAMD5Q7VIJ7, DXS_HELHP
B0TEJ5, DXS_HELMIB5ZAB7, DXS_HELPGQ1CUF6, DXS_HELPH
Q9ZM94, DXS_HELPJO25121, DXS_HELPYB0UUA4, DXS_HISS2
Q0C154, DXS_HYPNAQ5QVE8, DXS_IDILOB5Y0X1, DXS_KLEP3
A6T5F3, DXS_KLEP7B2GJ56, DXS_KOCRDA9KMB8, DXS_LACP7
C1DAW8, DXS_LARHHQ1MRB3, DXS_LAWIPQ6AFD5, DXS_LEIXX
Q04U59, DXS_LEPBJQ053M2, DXS_LEPBLB1Y2X5, DXS_LEPCP
Q72U01, DXS_LEPICQ8F153, DXS_LEPINQ92BZ0, DXS_LISIN
C1L2S1, DXS_LISMCQ71ZV7, DXS_LISMFQ8Y7C1, DXS_LISMO
A0AIG6, DXS_LISW6B1HRX4, DXS_LYSSCB9E6Q6, DXS_MACCJ
A0L6H3, DXS_MAGMMQ2W367, DXS_MAGSAQ8EWX7, DXS_MALP2
Q65TP4, DXS_MANSMQ0ARE5, DXS_MARMMA6VUE5, DXS_MARMS
Q60AN1, DXS_METCAQ1GZD7, DXS_METFKB3DW88, DXS_METI4
A2SJ46, DXS_METPPB0JL88, DXS_MICANQ2RIB9, DXS_MOOTA
A0QIL6, DXS_MYCA1B1MCU7, DXS_MYCA9P0A555, DXS_MYCBO
A1KM20, DXS_MYCBPC1AFE1, DXS_MYCBTA4TCS5, DXS_MYCGI
B8ZQW9, DXS_MYCLBQ50000, DXS_MYCLEQ73W57, DXS_MYCPA
A0QW19, DXS_MYCS2A3PYK6, DXS_MYCSJA1UF44, DXS_MYCSK
Q1B9W8, DXS_MYCSSA5U634, DXS_MYCTAP9WNS2, DXS_MYCTO
P9WNS3, DXS_MYCTUA0PT40, DXS_MYCUAA1T7Z0, DXS_MYCVP
Q1D3G4, DXS_MYXXDB2A526, DXS_NATTJQ5FAI2, DXS_NEIG1
B4RNW6, DXS_NEIG2A9M1G3, DXS_NEIM0Q9JW13, DXS_NEIMA
Q9JXV7, DXS_NEIMBA1KS32, DXS_NEIMFQ0AFY6, DXS_NITEC
Q82VD3, DXS_NITEUQ1QQ40, DXS_NITHXQ2YCH7, DXS_NITMU
Q3JAD1, DXS_NITOCA6Q1Z6, DXS_NITSBQ3SUZ1, DXS_NITWN
Q5YTA2, DXS_NOCFAA1SKM6, DXS_NOCSJB2J5P1, DXS_NOSP7
Q8YZ80, DXS_NOSS1Q2GC13, DXS_NOVADQ30Z99, DXS_OLEA2
A1R5N7, DXS_PAEATA6LFB9, DXS_PARD8Q7U6P6, DXS_PARMW
B2JP68, DXS_PARP8Q6MDK6, DXS_PARUWQ13RX1, DXS_PARXL
P57848, DXS_PASMUQ6D844, DXS_PECASC6DB37, DXS_PECCP
A5D2Z6, DXS_PELTSQ4FN07, DXS_PELUBB4RGW0, DXS_PHEZH
Q7N0J7, DXS_PHOLLQ6LU07, DXS_PHOPRA6L175, DXS_PHOV8
A1VMD7, DXS_POLNAQ12CQ9, DXS_POLSJB2RMK4, DXS_PORG3
Q7MSZ3, DXS_PORGIA3PCV0, DXS_PROM0A2C220, DXS_PROM1
A8G4R9, DXS_PROM2A2C9X1, DXS_PROM3A9BAC1, DXS_PROM4
A2BWN6, DXS_PROM5Q31AZ2, DXS_PROM9Q7VC14, DXS_PROMA
B4EU31, DXS_PROMHQ7V7Q3, DXS_PROMMQ7V1G6, DXS_PROMP
A2BR27, DXS_PROMSQ46L36, DXS_PROMTQ48NX0, DXS_PSE14
Q15W93, DXS_PSEA6A6V058, DXS_PSEA7B7V7R4, DXS_PSEA8
Q02SL1, DXS_PSEABQ9KGU7, DXS_PSEAEB8HH36, DXS_PSECP
Q1IFL1, DXS_PSEE4Q4K5A5, DXS_PSEF5C3K2R1, DXS_PSEFS
A4XZ25, DXS_PSEMYA5VXW9, DXS_PSEP1Q3K660, DXS_PSEPF
B0KL79, DXS_PSEPGQ88QG7, DXS_PSEPKB1J3G4, DXS_PSEPW
Q889Q1, DXS_PSESMQ3II09, DXS_PSET1Q4ZYU8, DXS_PSEU2
A4VQS8, DXS_PSEU5Q4FV64, DXS_PSYA2Q1QE74, DXS_PSYCK
A1SWW6, DXS_PSYINB2U930, DXS_RALPJQ8XX95, DXS_RALSO
A9WRA9, DXS_RENSMB3PS68, DXS_RHIE6Q2KBR2, DXS_RHIEC
Q1MKN4, DXS_RHIL3Q985Y3, DXS_RHILOB5ZS68, DXS_RHILW
Q92RJ1, DXS_RHIMEA5V6A9, DXS_RHIWRQ7UWB7, DXS_RHOBA
P26242, DXS_RHOCAB6IRB5, DXS_RHOCSC0ZYV9, DXS_RHOE4
Q0S1H1, DXS_RHOJRQ2IRL7, DXS_RHOP2Q07SR3, DXS_RHOP5
Q6NB76, DXS_RHOPAQ21A74, DXS_RHOPBQ130G7, DXS_RHOPS
B3QFY7, DXS_RHOPTB7JVJ6, DXS_RIPO1Q5LX42, DXS_RUEPO
Q1GCG4, DXS_RUESTQ21F93, DXS_SACD2A4FAQ5, DXS_SACEN
B5EXG3, DXS_SALA4A9MM42, DXS_SALARQ57SE2, DXS_SALCH
B5FKS7, DXS_SALDCB5QTH0, DXS_SALEPB5R6S3, DXS_SALG2
B4T8R3, DXS_SALHSB4SWR4, DXS_SALNSQ5PFR6, DXS_SALPA
A9MX09, DXS_SALPBC0Q7U7, DXS_SALPCB5BDB0, DXS_SALPK
B4TMA2, DXS_SALSVQ8Z8X3, DXS_SALTIQ8ZRD1, DXS_SALTY
A8GAP2, DXS_SERP5A1S8D4, DXS_SHEAMB8EAU7, DXS_SHEB2
A3D2B2, DXS_SHEB5A6WL04, DXS_SHEB8A9KTL5, DXS_SHEB9
Q12L26, DXS_SHEDOQ07ZD4, DXS_SHEFNB0TQ36, DXS_SHEHH
A3QGN9, DXS_SHELPQ8EGR9, DXS_SHEONA8H6X1, DXS_SHEPA
A4Y4X0, DXS_SHEPCB8CS19, DXS_SHEPWA0KZA9, DXS_SHESA
A8FYL0, DXS_SHESHQ0HGL5, DXS_SHESMQ0HSW6, DXS_SHESR
A1RLV3, DXS_SHESWB1KQY8, DXS_SHEWMB2U4M3, DXS_SHIB3
Q325I1, DXS_SHIBSQ32JH8, DXS_SHIDSQ83SG2, DXS_SHIFL
Q3Z4Y9, DXS_SHISSQ2NV94, DXS_SODGMQ1GQK9, DXS_SPHAL
Q9RBN6, DXS_STRC1B1VWJ8, DXS_STRGGB2FN57, DXS_STRMK
Q30TC5, DXS_SULDNQ67NB6, DXS_SYMTHQ2LUA7, DXS_SYNAS
Q3A3Z6, DXS_SYNC1Q8GAA0, DXS_SYNE7Q2JTX2, DXS_SYNJA
Q2JK64, DXS_SYNJBB1XKC5, DXS_SYNP2Q9R6S7, DXS_SYNP6
A5GL34, DXS_SYNPWA5GTT4, DXS_SYNR3Q0IAA6, DXS_SYNS3
Q3AXZ4, DXS_SYNS9Q3AJP8, DXS_SYNSCQ0AZE2, DXS_SYNWW
P73067, DXS_SYNY3Q47NL9, DXS_THEFYQ9X291, DXS_THEMA
A5ILK2, DXS_THEP1B9L1L6, DXS_THERPB1LAQ3, DXS_THESQ
Q72H81, DXS_THET2Q5SMD7, DXS_THET8Q8DL74, DXS_THEVB
Q3SKF1, DXS_THIDAB8GN62, DXS_THISHQ73LF4, DXS_TREDE
O83796, DXS_TREPAB2S462, DXS_TREPSQ10ZY2, DXS_TRIEI
Q3M4F6, DXS_TRIV2Q83I20, DXS_TROW8Q83G46, DXS_TROWT
A1WN06, DXS_VEREIB7VJA1, DXS_VIBA3A7MYC6, DXS_VIBC1
A5F331, DXS_VIBC3Q9KTL3, DXS_VIBCHC3LTD9, DXS_VIBCM
Q87RU0, DXS_VIBPAQ8DFA3, DXS_VIBVUQ7MN49, DXS_VIBVY
Q8D357, DXS_WIGBRQ7M7Z0, DXS_WOLSUQ8PJG7, DXS_XANAC
Q3BRW8, DXS_XANC5Q4UW29, DXS_XANC8Q8P815, DXS_XANCP
Q2P472, DXS_XANOMB2SQV8, DXS_XANOPQ5H1A0, DXS_XANOR
A7IPK6, DXS_XANP2B2I607, DXS_XYLF2Q9PB95, DXS_XYLFA
B0U3E1, DXS_XYLFMQ87C03, DXS_XYLFTA1JNR7, DXS_YERE8
A7FLE4, DXS_YERP3Q1C4I9, DXS_YERPAB2K6T7, DXS_YERPB
Q8ZC45, DXS_YERPEA9QZS3, DXS_YERPGQ1CL87, DXS_YERPN
A4TPG2, DXS_YERPPQ66DV4, DXS_YERPSB1JID8, DXS_YERPY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.2.1.-
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