ID   2.2.1.9
DE   2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid
DE   synthase.
AN   SEPHCHC synthase.
CA   2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-
CA   succinyl-cyclohex-3-ene-1-carboxylate + CO2.
CC   -!- Involved in the biosynthesis of vitamin K2 (menaquinone).
CC   -!- In most anaerobes and all Gram-positive aerobes, menaquinone is the
CC       sole electron transporter in the respiratory chain and is essential
CC       for their survival.
CC   -!- It had previously been thought that the products of the reaction were
CC       (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
CC       (SHCHC), pyruvate and CO2 but it is now known that two separate
CC       enzymes are involved: this enzyme and EC 4.2.99.20.
CC   -!- Under basic conditions, the product can spontaneously lose pyruvate
CC       to form SHCHC.
CC   -!- Formerly EC 2.5.1.64 and EC 2.5.1.n1.
DR   B0C1Y1, MEND_ACAM1 ;  A3N348, MEND_ACTP2 ;  B3GZ01, MEND_ACTP7 ;
DR   B0BSH8, MEND_ACTPJ ;  A6VMF8, MEND_ACTSZ ;  A0KFN8, MEND_AERHH ;
DR   A4SS26, MEND_AERS4 ;  B2UPN5, MEND_AKKM8 ;  Q5E480, MEND_ALIF1 ;
DR   A0JZP6, MEND_ARTS2 ;  A0RK76, MEND_BACAH ;  Q81K94, MEND_BACAN ;
DR   Q72YK6, MEND_BACC1 ;  A7GU91, MEND_BACCN ;  Q816H7, MEND_BACCR ;
DR   Q632I2, MEND_BACCZ ;  Q5LFS5, MEND_BACFN ;  Q64WR0, MEND_BACFR ;
DR   Q6HC26, MEND_BACHK ;  Q65FT2, MEND_BACLD ;  A9VM77, MEND_BACMK ;
DR   A8FGK9, MEND_BACP2 ;  P23970, MEND_BACSU ;  Q89YN0, MEND_BACTN ;
DR   A7Z812, MEND_BACVZ ;  Q6MHQ6, MEND_BDEBA ;  A9WB45, MEND_CHLAA ;
DR   Q3APX4, MEND_CHLCH ;  B3EG68, MEND_CHLL2 ;  Q3B612, MEND_CHLL3 ;
DR   B3QL00, MEND_CHLP8 ;  B3EMZ5, MEND_CHLPB ;  A1BI74, MEND_CHLPD ;
DR   A4SD60, MEND_CHLPM ;  Q8KBE8, MEND_CHLTE ;  A0M345, MEND_CHRFK ;
DR   A8ADW9, MEND_CITK8 ;  A5CUV9, MEND_CLAM3 ;  B0RCZ5, MEND_CLAMS ;
DR   Q6NJH8, MEND_CORDI ;  Q8FSB6, MEND_COREF ;  A4QBE1, MEND_CORGB ;
DR   Q4JT09, MEND_CORJK ;  B1WZR3, MEND_CROS5 ;  A7MHU4, MEND_CROS8 ;
DR   Q6A9B0, MEND_CUTAK ;  Q11U88, MEND_CYTH3 ;  Q47DK0, MEND_DECAR ;
DR   B8FTY8, MEND_DESHD ;  Q250I5, MEND_DESHY ;  Q6ARP3, MEND_DESPS ;
DR   A7ZP83, MEND_ECO24 ;  B7UFS7, MEND_ECO27 ;  B7MG32, MEND_ECO45 ;
DR   B7LAT0, MEND_ECO55 ;  Q8XDX8, MEND_ECO57 ;  B5YXQ8, MEND_ECO5E ;
DR   B7NNU4, MEND_ECO7I ;  B7MXE7, MEND_ECO81 ;  B7M5U7, MEND_ECO8A ;
DR   C4ZUA7, MEND_ECOBW ;  B1X8X8, MEND_ECODH ;  A8A2D2, MEND_ECOHS ;
DR   A1ADB6, MEND_ECOK1 ;  Q0TFH7, MEND_ECOL5 ;  Q8FFL1, MEND_ECOL6 ;
DR   B1IXS2, MEND_ECOLC ;  P17109, MEND_ECOLI ;  B7N5N0, MEND_ECOLU ;
DR   B6I7K8, MEND_ECOSE ;  B1LLL9, MEND_ECOSM ;  Q1R9E9, MEND_ECOUT ;
DR   C5B7I2, MEND_EDWI9 ;  A4WCP9, MEND_ENT38 ;  Q838J9, MEND_ENTFA ;
DR   B7LM66, MEND_ESCF3 ;  A5FG67, MEND_FLAJ1 ;  A6H070, MEND_FLAPJ ;
DR   Q5KVX6, MEND_GEOKA ;  A4IS14, MEND_GEOTN ;  B7K8M6, MEND_GLOC7 ;
DR   Q7VKM9, MEND_HAEDU ;  Q4QNQ7, MEND_HAEI8 ;  A5UAK7, MEND_HAEIE ;
DR   A5UGA0, MEND_HAEIG ;  P44612, MEND_HAEIN ;  A1WW41, MEND_HALHL ;
DR   B9LNE4, MEND_HALLT ;  Q5V3T2, MEND_HALMA ;  B0R4U1, MEND_HALS3 ;
DR   Q9HQN3, MEND_HALSA ;  Q18J11, MEND_HALWD ;  Q0I316, MEND_HISS1 ;
DR   B0UT51, MEND_HISS2 ;  A6W5P6, MEND_KINRD ;  B5XNX0, MEND_KLEP3 ;
DR   A6TBV8, MEND_KLEP7 ;  Q9CHK0, MEND_LACLA ;  A2RM73, MEND_LACLM ;
DR   Q030P1, MEND_LACLS ;  Q6AHC2, MEND_LEIXX ;  B1MZ27, MEND_LEUCK ;
DR   Q03Y61, MEND_LEUMM ;  Q92AY5, MEND_LISIN ;  Q71YZ2, MEND_LISMF ;
DR   Q8Y6K9, MEND_LISMO ;  A0AJC9, MEND_LISW6 ;  B1HY21, MEND_LYSSC ;
DR   Q65RK9, MEND_MANSM ;  B0JII8, MEND_MICAN ;  A0QLC9, MEND_MYCA1 ;
DR   B1MHC6, MEND_MYCA9 ;  Q7U1S4, MEND_MYCBO ;  A1KG32, MEND_MYCBP ;
DR   C1AKN5, MEND_MYCBT ;  A4T174, MEND_MYCGI ;  B8ZSY2, MEND_MYCLB ;
DR   Q9CBB0, MEND_MYCLE ;  B2HRP6, MEND_MYCMM ;  Q73SM1, MEND_MYCPA ;
DR   A0QRG5, MEND_MYCS2 ;  A3PUH9, MEND_MYCSJ ;  A1UAX3, MEND_MYCSK ;
DR   Q1BE13, MEND_MYCSS ;  A5TZT5, MEND_MYCTA ;  A1QNY1, MEND_MYCTF ;
DR   P9WK10, MEND_MYCTO ;  P9WK11, MEND_MYCTU ;  A0PLU9, MEND_MYCUA ;
DR   A1T3R3, MEND_MYCVP ;  Q1D6K1, MEND_MYXXD ;  Q3IQZ0, MEND_NATPD ;
DR   Q5YPA6, MEND_NOCFA ;  A1SE17, MEND_NOCSJ ;  Q8YZZ2, MEND_NOSS1 ;
DR   Q8CZD8, MEND_OCEIH ;  A1R996, MEND_PAEAT ;  A6LB35, MEND_PARD8 ;
DR   Q7U7I5, MEND_PARMW ;  Q6MCA7, MEND_PARUW ;  Q9CPI4, MEND_PASMU ;
DR   Q6D7W4, MEND_PECAS ;  C6DBP2, MEND_PECCP ;  B4SET5, MEND_PELPB ;
DR   Q7N2K3, MEND_PHOLL ;  Q6LNX3, MEND_PHOPR ;  A6L313, MEND_PHOV8 ;
DR   Q7MUI9, MEND_PORGI ;  B4S4J4, MEND_PROA2 ;  A3PBY1, MEND_PROM0 ;
DR   A2C165, MEND_PROM1 ;  A8G3X3, MEND_PROM2 ;  A2CAW2, MEND_PROM3 ;
DR   A2BVS0, MEND_PROM5 ;  Q31BS7, MEND_PROM9 ;  Q7VBN8, MEND_PROMA ;
DR   B4EZ42, MEND_PROMH ;  Q7V8E7, MEND_PROMM ;  Q7V277, MEND_PROMP ;
DR   A2BQ88, MEND_PROMS ;  Q46LU3, MEND_PROMT ;  A1SRV2, MEND_PSYIN ;
DR   A9WRT6, MEND_RENSM ;  C0ZV17, MEND_RHOE4 ;  Q0SF82, MEND_RHOJR ;
DR   C1AYZ0, MEND_RHOOB ;  B7K0T5, MEND_RIPO1 ;  A7NRP8, MEND_ROSCS ;
DR   A5UPB5, MEND_ROSS1 ;  Q1AS21, MEND_RUBXD ;  A4FPV1, MEND_SACEN ;
DR   B5EZI8, MEND_SALA4 ;  A9MJB6, MEND_SALAR ;  Q57M47, MEND_SALCH ;
DR   B5FPE8, MEND_SALDC ;  B5R2Z0, MEND_SALEP ;  B5RCD4, MEND_SALG2 ;
DR   B4TBH6, MEND_SALHS ;  B4SYY1, MEND_SALNS ;  Q5PN76, MEND_SALPA ;
DR   A9N5A2, MEND_SALPB ;  C0Q059, MEND_SALPC ;  B5BCN6, MEND_SALPK ;
DR   Q2S2V6, MEND_SALRD ;  B4TPJ2, MEND_SALSV ;  Q8Z533, MEND_SALTI ;
DR   Q8ZNE8, MEND_SALTY ;  A8GGZ1, MEND_SERP5 ;  A1SBA6, MEND_SHEAM ;
DR   A3CYZ9, MEND_SHEB5 ;  A6WTY4, MEND_SHEB8 ;  A9KU65, MEND_SHEB9 ;
DR   Q089C0, MEND_SHEFN ;  B0TNX0, MEND_SHEHH ;  A3QJ17, MEND_SHELP ;
DR   Q8E8T4, MEND_SHEON ;  A8H9P4, MEND_SHEPA ;  A4Y259, MEND_SHEPC ;
DR   A0L2B4, MEND_SHESA ;  A8FPR6, MEND_SHESH ;  Q0HDN7, MEND_SHESM ;
DR   Q0HPY8, MEND_SHESR ;  A1RPV7, MEND_SHESW ;  B1KM97, MEND_SHEWM ;
DR   B2TW50, MEND_SHIB3 ;  Q31YJ3, MEND_SHIBS ;  Q32DS4, MEND_SHIDS ;
DR   Q0T2L9, MEND_SHIF8 ;  Q821B0, MEND_SHIFL ;  Q3YZU2, MEND_SHISS ;
DR   A9GFL5, MEND_SORC5 ;  A7X0S7, MEND_STAA1 ;  A6U0L1, MEND_STAA2 ;
DR   Q2FI34, MEND_STAA3 ;  Q2FZL7, MEND_STAA8 ;  A5IRS9, MEND_STAA9 ;
DR   Q2YX30, MEND_STAAB ;  Q5HH40, MEND_STAAC ;  A6QFQ3, MEND_STAAE ;
DR   Q99V50, MEND_STAAM ;  Q7A6B1, MEND_STAAN ;  Q6GI39, MEND_STAAR ;
DR   Q6GAG9, MEND_STAAS ;  A8Z0D7, MEND_STAAT ;  Q8NXA2, MEND_STAAW ;
DR   Q5HQC5, MEND_STAEQ ;  Q8CPQ5, MEND_STAES ;  Q4L547, MEND_STAHJ ;
DR   Q49WG6, MEND_STAS1 ;  Q2LXE3, MEND_SYNAS ;  Q31NA4, MEND_SYNE7 ;
DR   Q2JY06, MEND_SYNJA ;  Q2JK10, MEND_SYNJB ;  Q5N5V7, MEND_SYNP6 ;
DR   A5GKI2, MEND_SYNPW ;  A5GT34, MEND_SYNR3 ;  Q0I9Z1, MEND_SYNS3 ;
DR   Q3AVF6, MEND_SYNS9 ;  Q3AKK3, MEND_SYNSC ;  Q55725, MEND_SYNY3 ;
DR   Q47Q20, MEND_THEFY ;  Q8DMI6, MEND_THEVB ;  Q10XD8, MEND_TRIEI ;
DR   Q3M3Y3, MEND_TRIV2 ;  B7VHY7, MEND_VIBA3 ;  A7MZS0, MEND_VIBC1 ;
DR   A5F6T1, MEND_VIBC3 ;  Q9KQM3, MEND_VIBCH ;  C3LNS6, MEND_VIBCM ;
DR   Q87R69, MEND_VIBPA ;  Q8D820, MEND_VIBVU ;  Q7MMF6, MEND_VIBVY ;
DR   A1JKT8, MEND_YERE8 ;  A7FGT2, MEND_YERP3 ;  Q1C6D7, MEND_YERPA ;
DR   B2K7Z3, MEND_YERPB ;  Q7CJ76, MEND_YERPE ;  A9R6J0, MEND_YERPG ;
DR   Q1CHS9, MEND_YERPN ;  A4TM08, MEND_YERPP ;  Q669C7, MEND_YERPS ;
DR   B1JH88, MEND_YERPY ;  Q15KI9, PHYLO_ARATH;
//