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ENZYME entry: EC 2.3.1.135

Accepted Name
Phosphatidylcholine--retinol O-acyltransferase.
Alternative Name(s)
Lecithin retinol acyl transferase.
Lecithin--retinol acyltransferase.
Lecithin-retinol acyltransferase.
Retinyl ester synthase.
Reaction catalysed
Phosphatidylcholine + retinol--[cellular-retinol-binding-protein] <=> 2-acylglycerophosphocholine + retinyl-ester--[cellular-retinol-binding-protein]
Comment(s)
  • A key enzyme in retinoid metabolism, catalyzing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored.
  • Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form.
  • Can also esterify 11-cis-retinol.
Cross-references
BRENDA2.3.1.135
EC2PDB2.3.1.135
ExplorEnz2.3.1.135
PRIAM enzyme-specific profiles2.3.1.135
KEGG Ligand Database for Enzyme Nomenclature2.3.1.135
IUBMB Enzyme Nomenclature2.3.1.135
IntEnz2.3.1.135
MEDLINEFind literature relating to 2.3.1.135
MetaCyc2.3.1.135
UniProtKB/Swiss-Prot
Q9BGL2, LRAT_BOVIN;  O95237, LRAT_HUMAN;  Q9JI60, LRAT_MOUSE;  
Q9JI61, LRAT_RAT;  

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