ENZYME entry: EC 2.3.1.135
| Accepted Name |
|---|
| Phosphatidylcholine--retinol O-acyltransferase.
|
| Alternative Name(s) |
|---|
| Lecithin retinol acyl transferase. |
| Lecithin--retinol acyltransferase. |
| Lecithin-retinol acyltransferase. |
| Retinyl ester synthase. |
| Reaction catalysed |
|---|
| Phosphatidylcholine + retinol--[cellular-retinol-binding-protein] <=> 2-acylglycerophosphocholine + retinyl-ester--[cellular-retinol-binding-protein] |
| Comment(s) |
|---|
- A key enzyme in retinoid metabolism, catalyzing the transfer of an
acyl group from the sn-1 position of phosphatidylcholine to retinol,
forming retinyl esters which are then stored.
- Recognizes the substrate both in free form and when bound to
cellular-retinol-binding-protein, but has higher affinity for the
bound form.
- Can also esterify 11-cis-retinol.
|
| Cross-references |
|---|
| BRENDA | 2.3.1.135 |
| EC2PDB | 2.3.1.135 |
| ExplorEnz | 2.3.1.135 |
| PRIAM enzyme-specific profiles | 2.3.1.135 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.135 |
| IUBMB Enzyme Nomenclature | 2.3.1.135 |
| IntEnz | 2.3.1.135 |
| MEDLINE | Find literature relating to 2.3.1.135 |
| MetaCyc | 2.3.1.135 |
| UniProtKB/Swiss-Prot |
|
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