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ENZYME entry: EC 2.3.1.149

Accepted Name
Platelet-activating factor acetyltransferase.
Alternative Name(s)
PAF acetyltransferase.
Reaction catalysed
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid <=> 1-organyl-2-lyso-sn-glycero-3-phosphocholine + 1-alkyl-2-acetyl-sn-glycero-3-phospholipid
Comment(s)
  • Catalyzes the transfer of the acetyl group from 1-alkyl-2-acyl- sn-glycero-3-phosphocholine (platelet-activating factor) to the sn-2 position of lyso-glycerophospholipids containing ethanolamine, choline, serine, inositol or phosphate groups at the sn-3 position as well as to sphingosine and long-chain fatty alcohols.
  • The organyl group can be alkyl, acyl or alk-1-enyl (sometimes also collectively referred to as 'radyl').
Cross-references
BRENDA2.3.1.149
EC2PDB2.3.1.149
ExplorEnz2.3.1.149
PRIAM enzyme-specific profiles2.3.1.149
KEGG Ligand Database for Enzyme Nomenclature2.3.1.149
IUBMB Enzyme Nomenclature2.3.1.149
IntEnz2.3.1.149
MEDLINEFind literature relating to 2.3.1.149
MetaCyc2.3.1.149
UniProtKB/Swiss-Prot
P79106, PAFA2_BOVIN;  Q99487, PAFA2_HUMAN;  Q8VDG7, PAFA2_MOUSE;  
P83006, PAFA2_RAT;  

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