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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Phospholipid:diacylglycerol acyltransferase.
Alternative Name(s)
Reaction catalysed
Phospholipid + 1,2-diacyl-sn-glycerol <=> lysophospholipid + triacylglycerol
  • This enzyme differs from EC by synthesising triacylglycerol using an acyl-CoA-independent mechanism.
  • The specificity of the enzyme for the acyl group in the phospholipid varies with species, e.g., the enzyme from castor bean (Ricinus communis) preferentially incorporates vernoloyl (12,13-epoxyoctadec- 9-enoyl) groups into triacylglycerol, whereas that from the hawk's beard (Crepis palaestina) incorporates both ricinoleoyl (12-hydroxyoctadec-9-enoyl) and vernoloyl groups.
  • The enzyme from the yeast Saccharomyces cerevisiae specifically transfers acyl groups from the sn-2 position of the phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid.
PRIAM enzyme-specific profiles2.3.1.158
KEGG Ligand Database for Enzyme Nomenclature2.3.1.158
IUBMB Enzyme Nomenclature2.3.1.158
MEDLINEFind literature relating to
P40345, PDAT_YEAST;  

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