ENZYME entry: EC 2.3.1.158
Accepted Name |
Phospholipid:diacylglycerol acyltransferase.
|
Alternative Name(s) |
PDAT. |
Reaction catalysed |
Phospholipid + 1,2-diacyl-sn-glycerol <=> lysophospholipid + triacylglycerol |
Comment(s) |
- This enzyme differs from EC 2.3.1.20 by synthesising triacylglycerol
using an acyl-CoA-independent mechanism.
- The specificity of the enzyme for the acyl group in the phospholipid
varies with species, e.g., the enzyme from castor bean (Ricinus
communis) preferentially incorporates vernoloyl (12,13-epoxyoctadec-
9-enoyl) groups into triacylglycerol, whereas that from the hawk's
beard (Crepis palaestina) incorporates both ricinoleoyl
(12-hydroxyoctadec-9-enoyl) and vernoloyl groups.
- The enzyme from the yeast Saccharomyces cerevisiae specifically
transfers acyl groups from the sn-2 position of the phospholipid to
diacylglycerol, thus forming an sn-1-lysophospholipid.
|
Cross-references |
BRENDA | 2.3.1.158 |
EC2PDB | 2.3.1.158 |
ExplorEnz | 2.3.1.158 |
PRIAM enzyme-specific profiles | 2.3.1.158 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.158 |
IUBMB Enzyme Nomenclature | 2.3.1.158 |
IntEnz | 2.3.1.158 |
MEDLINE | Find literature relating to 2.3.1.158 |
MetaCyc | 2.3.1.158 |
UniProtKB/Swiss-Prot |
|
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