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ENZYME entry: EC 2.3.1.158

Accepted Name
phospholipid:diacylglycerol acyltransferase.
Alternative Name(s)
PDAT.
Reaction catalysed
a 1,2-diacyl-sn-glycerol + a glycerophospholipid <=> a monoacylglycerophospholipid + a triacyl-sn-glycerol
Comment(s)
  • This enzyme differs from EC 2.3.1.20 by synthesizing triacylglycerol using an acyl-CoA-independent mechanism.
  • The specificity of the enzyme for the acyl group in the phospholipid varies with species, e.g., the enzyme from castor bean (Ricinus communis) preferentially incorporates vernoloyl (12,13-epoxyoctadec- 9-enoyl) groups into triacylglycerol, whereas that from the hawk's beard (Crepis palaestina) incorporates both ricinoleoyl (12-hydroxyoctadec-9-enoyl) and vernoloyl groups.
  • The enzyme from the yeast Saccharomyces cerevisiae specifically transfers acyl groups from the sn-2 position of the phospholipid to diacylglycerol, thus forming an sn-1-lysophospholipid.
Cross-references
BRENDA2.3.1.158
EC2PDB2.3.1.158
ExplorEnz2.3.1.158
PRIAM enzyme-specific profiles2.3.1.158
KEGG Ligand Database for Enzyme Nomenclature2.3.1.158
IUBMB Enzyme Nomenclature2.3.1.158
IntEnz2.3.1.158
MEDLINEFind literature relating to 2.3.1.158
MetaCyc2.3.1.158
Rhea expert-curated reactions2.3.1.158
UniProtKB/Swiss-Prot
Q9FNA9, PDAT1_ARATH;  Q9FYC7, PDAT2_ARATH;  O94680, PDAT_SCHPO;  
P40345, PDAT_YEAST;  

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