ID   2.3.1.161
DE   lovastatin nonaketide synthase.
CA   19 H(+) + holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA +
CA   11 NADPH + S-adenosyl-L-methionine = 9 CO2 + 9 CoA + dihydromonacolin
CA   L-[lovastatin nonaketide synthase] + 6 H2O + 11 NADP(+) + S-adenosyl-L-
CA   homocysteine.
CC   -!- This fungal enzyme system comprises a multi-functional polyketide
CC       synthase (PKS) and an enoyl reductase.
CC   -!- The PKS catalyzes many of the chain building reactions of
CC       EC 2.3.1.85, as well as a reductive methylation and a Diels-Alder
CC       reaction, while the reductase is responsible for three enoyl
CC       reductions that are necessary for dihydromonacolin L acid production.
DR   Q9Y8A5, LOVB_ASPTE ;  Q0C8M3, LOVB_ASPTN ;  Q9Y7D0, LOVC_ASPTE ;
DR   Q0C8M1, LOVC_ASPTN ;  Q3S2T9, MOKA_MONPI ;
//