ID 2.3.1.161 DE lovastatin nonaketide synthase. CA holo-[lovastatin nonaketide synthase] + 9 malonyl-CoA + S-adenosyl-L- CA methionine + 11 NADPH + 19 H(+) = dihydromonacolin L-[lovastatin CA nonaketide synthase] + S-adenosyl-L-homocysteine + 9 CO2 + 11 NADP(+) + CA 9 CoA + 6 H2O. CC -!- This fungal enzyme system comprises a multi-functional polyketide CC synthase (PKS) and an enoyl reductase. CC -!- The PKS catalyzes many of the chain building reactions of CC EC 2.3.1.85, as well as a reductive methylation and a Diels-Alder CC reaction, while the reductase is responsible for three enoyl CC reductions that are necessary for dihydromonacolin L acid production. DR Q9Y8A5, LOVB_ASPTE ; Q0C8M3, LOVB_ASPTN ; Q9Y7D0, LOVC_ASPTE ; DR Q0C8M1, LOVC_ASPTN ; Q3S2T9, MOKA_MONPI ; //