ID   2.3.1.161
DE   Lovastatin nonaketide synthase.
CA   9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + holo-[lovastatin
CA   nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide
CA   synthase] + 9 CoA + 9 CO(2) + 11 NADP(+) + S-adenosyl-L-homocysteine +
CA   6 H(2)O.
CC   -!- This fungal enzyme system comprises a multi-functional polyketide
CC       synthase (PKS) and an enoyl reductase.
CC   -!- The PKS catalyzes many of the chain building reactions of
CC       EC 2.3.1.85, as well as a reductive methylation and a Diels-Alder
CC       reaction, while the reductase is responsible for three enoyl
CC       reductions that are necessary for dihydromonacolin L acid production.
PR   PROSITE; PDOC00529;
DR   Q9Y8A5, LOVB_ASPTE ;  Q0C8M3, LOVB_ASPTN ;  Q9Y7D0, LOVC_ASPTE ;
DR   Q0C8M1, LOVC_ASPTN ;  Q3S2T9, MOKA_MONPI ;
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