ENZYME entry: EC 2.3.1.162
| Accepted Name | |||
|---|---|---|---|
| taxadien-5alpha-ol O-acetyltransferase | |||
| Alternative Name(s) | |||
| taxa-4(20),11(12)-dien-5alpha-ol O-acetyltransferase | |||
| taxadienol acetyltransferase | |||
| Reaction catalysed | |||
| acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate | |||
| Comment(s) | |||
| This is the third enzyme in the biosynthesis of the diterpenoid antineoplastic drug taxol (paclitaxel), which is widely used in the treatment of carcinomas, sarcomas and melanomas. | |||
| Cross-references | |||
| BRENDA | 2.3.1.162 | ||
| EC2PDB | 2.3.1.162 | ||
| ExplorEnz | 2.3.1.162 | ||
| PRIAM enzyme-specific profiles | 2.3.1.162 | ||
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.162 | ||
| IUBMB Enzyme Nomenclature | 2.3.1.162 | ||
| IntEnz | 2.3.1.162 | ||
| MEDLINE | Find literature relating to 2.3.1.162 | ||
| MetaCyc | 2.3.1.162 | ||
| Rhea expert-curated reactions | 2.3.1.162 | ||
| UniProtKB/Swiss-Prot |
| ||
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