ID 2.3.1.168 DE dihydrolipoyllysine-residue (2-methylpropanoyl)transferase. AN dihydrolipoyl transacylase. CA 2-methylpropanoyl-CoA + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] = CA CoA + N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein]. CC -!- A multimer (24-mer) of this enzyme forms the core of the multienzyme CC 3-methyl-2-oxobutanoate dehydrogenase complex, and binds tightly both CC EC 1.2.4.4 and EC 1.8.1.4. CC -!- The lipoyl group of this enzyme is reductively 2-methylpropanoylated CC by EC 1.2.4.4, and the only observed direction catalyzed by CC EC 2.3.1.168 is that where this 2-methylpropanoyl is passed to CC coenzyme A. CC -!- In addition to the 2-methylpropanoyl group, formed when EC 1.2.4.4 CC acts on the oxoacid that corresponds with valine, this enzyme also CC transfers the 3-methylbutanoyl and S-2-methylbutanoyl groups, donated CC to it when EC 1.2.4.4 acts on the oxo acids corresponding with CC leucine and isoleucine. DR O06159, BKDC_MYCTU ; Q9M7Z1, ODB2_ARATH ; P37942, ODB2_BACSU ; DR P11181, ODB2_BOVIN ; Q23571, ODB2_CAEEL ; P11182, ODB2_HUMAN ; DR P53395, ODB2_MOUSE ; Q9I1M0, ODB2_PSEAE ; P09062, ODB2_PSEPU ; //