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ENZYME

ENZYME entry: EC 2.3.1.184

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.184
Accepted Name
acyl-homoserine-lactone synthase
Alternative Name(s)
acylhomoserine lactone synthase
acyl homoserine lactone synthase
acyl-homoserinelactone synthase
acyl-homoserine lactone synthase
AHL synthase
AHSL synthase
autoinducer synthase
autoinducer synthesis protein
N-acyl homoserine lactone synthase
Reaction catalysed
a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-homoserine lactone + S-methyl-5'-thioadenosine + holo-[ACP] + H(+)
Comment(s)
  • Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing.
  • Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signaling which, in turn, initiates the expression of particular virulence genes.
  • N-(3-oxohexanoyl)-[acyl-carrier-protein] and hexanoyl-[acyl-carrier- protein] are the best substrates.
  • The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier-protein] rather than from fatty-acid degradation through acyl-CoA.
  • S-Adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone.
Cross-references
BRENDA2.3.1.184
EC2PDB2.3.1.184
ExplorEnz2.3.1.184
KEGG Ligand Database for Enzyme Nomenclature2.3.1.184
IUBMB Enzyme Nomenclature2.3.1.184
MEDLINEFind literature relating to 2.3.1.184
MetaCyc2.3.1.184
Rhea expert-curated reactions2.3.1.184
UniProtKB/Swiss-Prot
B0FLN1, ABAI_ACIBAQ44058, AHYI_AERHYA0A0A7XNA3, ANOI_ACINO
P70774, ASAI_AERSAP33880, CARI_PECCCP33881, EAGI_ENTAG
Q46968, ECHI_DICCHP54656, ESAI_PANSEQ47187, EXPI_DICD3
P33882, EXPI_PECPMP33883, LASI_PSEAEP12747, LUXI_ALIFS
P35328, LUXJ_ALIF1B7VQM9, LUXM_VIBA3A7MRY3, LUXM_VIBC1
P54298, LUXM_VIBHAQ87NA8, OPAM_VIBPAQ51522, PHZI_PSECL
Q51785, PHZI_PSEFLP52990, PSYI_PSEAJO54451, RAII_RHIET
P54291, RHLI_PSEAEP58584, SOLI_RALN1O30920, SOLI_RALSL
P52989, SWRI_SERLIP33907, TRAI_AGRFCP33904, TRAI_AGRTU
P55394, TRAI_SINFNP74945, VANI_VIBANQ9FDA3, VANM_VIBAN
P52988, YENI_YERENO87970, YUKI_YERRU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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