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ENZYME entry: EC 2.3.1.185

Accepted Name
Tropine acyltransferase.
Alternative Name(s)
TAT.
Tropine acetyltransferase.
Tropine tigloyltransferase.
Reaction catalysed
An acyl-CoA + tropine <=> CoA + an O-acyltropine
Comment(s)
  • Exhibits absolute specificity for the endo/3-alpha configuration found in tropine as pseudotropine (tropan-3-beta-ol; see EC 2.3.1.186) is not a substrate.
  • Acts on a wide range of aliphatic acyl-CoA derivatives, with tigloyl- CoA and acetyl-CoA being the best substrates.
  • It is probably involved in the formation of the tropane alkaloid littorine, which is a precursor of hyoscyamine.
Cross-references
BRENDA2.3.1.185
EC2PDB2.3.1.185
ExplorEnz2.3.1.185
PRIAM enzyme-specific profiles2.3.1.185
KEGG Ligand Database for Enzyme Nomenclature2.3.1.185
IUBMB Enzyme Nomenclature2.3.1.185
IntEnz2.3.1.185
MEDLINEFind literature relating to 2.3.1.185
MetaCyc2.3.1.185
Rhea expert-curated reactions2.3.1.185

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