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ENZYME

ENZYME entry: EC 2.3.1.189

Accepted Name
mycothiol synthase
Reaction catalysed
1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA <=> CoA + H(+) + mycothiol
Comment(s)
  • This enzyme catalyzes the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium.
  • The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs).
  • The enzyme has been purified from Mycobacterium tuberculosis H37Rv.
  • Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate.
Cross-references
BRENDA2.3.1.189
EC2PDB2.3.1.189
ExplorEnz2.3.1.189
PRIAM enzyme-specific profiles2.3.1.189
KEGG Ligand Database for Enzyme Nomenclature2.3.1.189
IUBMB Enzyme Nomenclature2.3.1.189
IntEnz2.3.1.189
MEDLINEFind literature relating to 2.3.1.189
MetaCyc2.3.1.189
Rhea expert-curated reactions2.3.1.189
UniProtKB/Swiss-Prot
A0LWI8, MSHD_ACIC1C7M077, MSHD_ACIFDC6WPR7, MSHD_ACTMD
Q5EDG0, MSHD_AMYMUA0JZC2, MSHD_ARTS2C5C246, MSHD_BEUC1
C7MGB3, MSHD_BRAFDC7QKH8, MSHD_CATADD5UJR1, MSHD_CELFN
A5CTZ8, MSHD_CLAM3B0RAV5, MSHD_CLASEC3PIU4, MSHD_CORA7
Q6NFH9, MSHD_CORDIQ8FMN5, MSHD_COREFA4QGX4, MSHD_CORGB
Q8NMJ7, MSHD_CORGLQ4JXC9, MSHD_CORJKC4LH71, MSHD_CORK4
B1VII5, MSHD_CORU7Q0RS64, MSHD_FRAAAQ2JFW4, MSHD_FRACC
A8LDL3, MSHD_FRASND2S4P5, MSHD_GEOOGD0L3V5, MSHD_GORB4
C7R1N6, MSHD_JONDDA6W6C7, MSHD_KINRDB2GI63, MSHD_KOCRD
D2Q187, MSHD_KRIFDC7NK43, MSHD_KYTSDC5CC88, MSHD_MICLC
A0QAU8, MSHD_MYCA1B1MI19, MSHD_MYCA9Q7U173, MSHD_MYCBO
A1KGV2, MSHD_MYCBPC1ALF4, MSHD_MYCBTA4T7H0, MSHD_MYCGI
B8ZSU0, MSHD_MYCLBQ9CBC9, MSHD_MYCLEB2HH13, MSHD_MYCMM
Q743D5, MSHD_MYCPAA4ZHT6, MSHD_MYCS2A3Q695, MSHD_MYCSJ
A1ULU4, MSHD_MYCSKQ1B3A6, MSHD_MYCSSA5U0K8, MSHD_MYCTA
A5WKI8, MSHD_MYCTFC6DVC4, MSHD_MYCTKP9WJM6, MSHD_MYCTO
P9WJM7, MSHD_MYCTUA0PLC7, MSHD_MYCUAA1TFB7, MSHD_MYCVP
C8XA55, MSHD_NAKMYD7AWZ7, MSHD_NOCDDQ5Z297, MSHD_NOCFA
A1SPL0, MSHD_NOCSJA1R8Y2, MSHD_PAEATD7GG24, MSHD_PROFC
B8HD44, MSHD_PSECPA9WNI5, MSHD_RENSMC0ZP17, MSHD_RHOE4
Q0S740, MSHD_RHOJRC1ATC6, MSHD_RHOOBD2NRH2, MSHD_ROTMD
A4FQD4, MSHD_SACENC7MRC4, MSHD_SACVDA8LYQ4, MSHD_SALAI
A4X1M6, MSHD_SALTOD1BE23, MSHD_SANKSD6ZEJ5, MSHD_SEGRD
D3Q4A8, MSHD_STANLQ82G40, MSHD_STRAWD7C376, MSHD_STRBB
Q9KZV0, MSHD_STRCOB1VS15, MSHD_STRGGD2B7W7, MSHD_STRRD
C9ZFL1, MSHD_STRSWD6Y4C5, MSHD_THEBDD1A4F4, MSHD_THECD
Q47LA0, MSHD_THEFYD5UXA4, MSHD_TSUPDD1BV84, MSHD_XYLCX

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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