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ENZYME

ENZYME entry: EC 2.3.1.193

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.193
Accepted Name
tRNA(Met) cytidine acetyltransferase
Reaction catalysed
cytidine(34) in elongator tRNA(Met) + acetyl-CoA + ATP + H2O = N(4)-acetylcytidine(34) in elongator tRNA(Met) + ADP + phosphate + CoA + H(+)
Comment(s)
  • The enzyme acetylates the wobble base C34 of the CAU anticodon of elongation-specific tRNA(Met).
  • Escherichia coli TmcA strictly discriminates elongator tRNA(Met) from tRNA(Ile), which is structurally similar and has the same anticodon loop, mainly by recognizing the C27-G43 pair in the anticodon stem.
  • The enzyme can use GTP in place of ATP for formation of N(4)- acetylcytidine.
Cross-references
BRENDA2.3.1.193
EC2PDB2.3.1.193
ExplorEnz2.3.1.193
KEGG Ligand Database for Enzyme Nomenclature2.3.1.193
IUBMB Enzyme Nomenclature2.3.1.193
MEDLINEFind literature relating to 2.3.1.193
MetaCyc2.3.1.193
Rhea expert-curated reactions2.3.1.193
UniProtKB/Swiss-Prot
Q980C5, TMCA1_SACS2Q97U12, TMCA2_SACS2A3N059, TMCA_ACTP2
Q9YBQ6, TMCA_AERPEA8ADB3, TMCA_CITK8P76562, TMCA_ECOLI
Q7VLN6, TMCA_HAEDUP44140, TMCA_HAEINQ5V5M5, TMCA_HALMA
D4GW73, TMCA_HALVDQ5QY69, TMCA_IDILOQ8TYZ5, TMCA_METKA
D5C1K8, TMCA_NITHNQ6D7Q9, TMCA_PECASC7BGY4, TMCA_PHOAA
Q9UZ78, TMCA_PYRABQ8U3G4, TMCA_PYRFUC3N792, TMCA_SACI7
Q8ZN74, TMCA_SALTYQ0T243, TMCA_SHIF8Q5JHC6, TMCA_THEKO
A1RY08, TMCA_THEPDB7R4L8, TMCA_THES3Q9KKJ5, TMCA_VIBCH
A1JL12, TMCA_YERE8D0JFM7, TMCA_YERPD

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-