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ENZYME entry: EC 2.3.1.193

Accepted Name
tRNA(Met) cytidine acetyltransferase
Reaction catalysed
acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O <=> ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate
Comment(s)
  • The enzyme acetylates the wobble base C34 of the CAU anticodon of elongation-specific tRNA(Met).
  • Escherichia coli TmcA strictly discriminates elongator tRNA(Met) from tRNA(Ile), which is structurally similar and has the same anticodon loop, mainly by recognizing the C27-G43 pair in the anticodon stem.
  • The enzyme can use GTP in place of ATP for formation of N(4)- acetylcytidine.
Cross-references
BRENDA2.3.1.193
EC2PDB2.3.1.193
ExplorEnz2.3.1.193
PRIAM enzyme-specific profiles2.3.1.193
KEGG Ligand Database for Enzyme Nomenclature2.3.1.193
IUBMB Enzyme Nomenclature2.3.1.193
IntEnz2.3.1.193
MEDLINEFind literature relating to 2.3.1.193
MetaCyc2.3.1.193
Rhea expert-curated reactions2.3.1.193
UniProtKB/Swiss-Prot
A3N059, TMCA_ACTP2Q9YBQ6, TMCA_AERPEA8ADB3, TMCA_CITK8
P76562, TMCA_ECOLIQ7VLN6, TMCA_HAEDUP44140, TMCA_HAEIN
Q5V5M5, TMCA_HALMAD4GW73, TMCA_HALVDQ5QY69, TMCA_IDILO
Q8TYZ5, TMCA_METKAD5C1K8, TMCA_NITHNQ6D7Q9, TMCA_PECAS
C7BGY4, TMCA_PHOAAQ9UZ78, TMCA_PYRABQ8ZN74, TMCA_SALTY
Q0T243, TMCA_SHIF8C3N792, TMCA_SULIYA1RY08, TMCA_THEPD
Q9KKJ5, TMCA_VIBCHA1JL12, TMCA_YERE8D0JFM7, TMCA_YERPD

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