ID 2.3.1.219 DE demethoxycurcumin synthase. CA (1) (E)-4-coumaroyl-CoA + (E)-feruloylacetyl-CoA + H2O = CO2 + 2 CoA + CA demethoxycurcumin. CA (2) (4-coumaroyl)acetyl-CoA + 4-coumaroyl-CoA + H2O = CA bisdemethoxycurcumin + CO2 + 2 CoA. CC -!- A polyketide synthase from the plant Curcuma longa (turmeric). CC -!- Three isoforms exist, CURS1, CURS2 and CURS3. CC -!- While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate (cf. CC EC 2.3.1.217), CURS3 can accept 4-coumaroyl-CoA equally well. DR C6L7V9, CURS3_CURLO; //