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ENZYME

ENZYME entry: EC 2.3.1.225

Accepted Name
protein S-acyltransferase
Alternative Name(s)
DHHC palmitoyl transferase
G-protein palmitoyltransferase
S-protein acyltransferase
Reaction catalysed
hexadecanoyl-CoA + L-cysteinyl-[protein] <=> CoA + S-hexadecanoyl-L-cysteinyl-[protein]
Comment(s)
  • The enzyme catalyzes the post-translational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity.
  • Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association.
Cross-references
BRENDA2.3.1.225
EC2PDB2.3.1.225
ExplorEnz2.3.1.225
PRIAM enzyme-specific profiles2.3.1.225
KEGG Ligand Database for Enzyme Nomenclature2.3.1.225
IUBMB Enzyme Nomenclature2.3.1.225
IntEnz2.3.1.225
MEDLINEFind literature relating to 2.3.1.225
MetaCyc2.3.1.225
Rhea expert-curated reactions2.3.1.225
UniProtKB/Swiss-Prot
Q4X251, AKR1_ASPFUQ7Z8U2, AKR1_ASPORQ5AL27, AKR1_CANAL
Q6FJ70, AKR1_CANGAP0CS67, AKR1_CRYNBP0CS66, AKR1_CRYNJ
Q6BP80, AKR1_DEBHAQ5B0V6, AKR1_EMENIQ755Y0, AKR1_EREGS
Q4I8B6, AKR1_GIBZEQ875M2, AKR1_KLULAQ875S9, AKR1_LACK1
Q9UVH3, AKR1_MORAPQ876A6, AKR1_NAUCCQ7S3M5, AKR1_NEUCR
Q876L5, AKR1_SACU7Q09701, AKR1_SCHPOQ4P6L3, AKR1_USTMA
Q6C520, AKR1_YARLIP39010, AKR1_YEASTQ876L4, AKR2_SACU7
Q12013, AKR2_YEASTA2VEY9, APP_DROMEF1RE57, DHC3A_DANRE
Q2THW0, DHC5A_DANREE7FBS9, DHC5B_DANREQ4WWN2, ERFB_ASPFU
Q59QL0, ERFB_CANALQ6FSS4, ERFB_CANGAQ6BHT4, ERFB_DEBHA
Q5B3W7, ERFB_EMENIQ750R7, ERFB_EREGSQ4I2M7, ERFB_GIBZE
Q6CQB5, ERFB_KLULAQ7SFL7, ERFB_NEUCRO74384, ERFB_SCHPO
Q6C890, ERFB_YARLIQ06551, ERFB_YEASTQ9QY94, GLNA_ACOCA
P15103, GLNA_BOVINQ8HZM5, GLNA_CANLFP04773, GLNA_CRIGR
P15104, GLNA_HUMANQ4R7U3, GLNA_MACFAP15105, GLNA_MOUSE
P46410, GLNA_PIGP09606, GLNA_RATQ9VUW9, HIP14_DROME
Q4WZL8, PFA3_ASPFUQ5ADN9, PFA3_CANALQ6FW70, PFA3_CANGA
Q6BMV2, PFA3_DEBHAC8VCL4, PFA3_EMENIQ75AW7, PFA3_EREGS
Q4IA62, PFA3_GIBZEQ6CPU8, PFA3_KLULAQ7S7C5, PFA3_NEUCR
O14345, PFA3_SCHPOQ6C4W5, PFA3_YARLIP42836, PFA3_YEAST
Q4WC37, PFA4_ASPFUQ5AGV7, PFA4_CANALQ6FVE6, PFA4_CANGA
P0CS69, PFA4_CRYNBJ9VJ99, PFA4_CRYNHP0CS68, PFA4_CRYNJ
Q6BLY8, PFA4_DEBHAQ5BD15, PFA4_EMENIQ75CB4, PFA4_EREGS
Q4IMZ7, PFA4_GIBZEQ6CUB5, PFA4_KLULAQ7SCY6, PFA4_NEUCR
Q4PE27, PFA4_USTMAQ6C7Q0, PFA4_YARLIQ12006, PFA4_YEAST
Q4WUK1, PFA5_ASPFUQ59NR8, PFA5_CANALQ6FMP5, PFA5_CANGA
Q6BP97, PFA5_DEBHAQ5B433, PFA5_EMENIQ75D19, PFA5_EREGS
Q4I1J3, PFA5_GIBZEQ6CRV3, PFA5_KLULAQ9C0W9, PFA5_SCHPO
Q6C7D1, PFA5_YARLIQ03289, PFA5_YEASTQ4WN54, SWF1_ASPFU
Q5A861, SWF1_CANALQ6FXC6, SWF1_CANGAQ6BP23, SWF1_DEBHA
Q5BC23, SWF1_EMENIQ74ZZ2, SWF1_EREGSQ6CJC5, SWF1_KLULA
Q7RWM9, SWF1_NEUCRO60069, SWF1_SCHPOQ6CG20, SWF1_YARLI
Q04629, SWF1_YEASTB0S5D5, ZD12A_DANREE7F021, ZD12B_DANRE
B8A4F0, ZD16A_DANREA0A0R4IF99, ZD16B_DANREE7FH11, ZD18A_DANRE
Q7ZVN4, ZD18B_DANREF1Q7H8, ZD20A_DANREE7F587, ZD20B_DANRE
F1QHM7, ZD23A_DANREF1QX91, ZD23B_DANREQ9M306, ZDH10_ARATH
Q7XA86, ZDH11_ARATHE7EZI4, ZDH11_DANREQ9H8X9, ZDH11_HUMAN
Q14AK4, ZDH11_MOUSEB3DN87, ZDH12_ARATHQ96GR4, ZDH12_HUMAN
Q8VC90, ZDH12_MOUSEQ6DGF5, ZDH12_RATQ9M1K5, ZDH13_ARATH
Q8IUH4, ZDH13_HUMANQ4R690, ZDH13_MACFAQ9CWU2, ZDH13_MOUSE
Q5NVB9, ZDH13_PONABQ8VYP5, ZDH14_ARATHE9QCD3, ZDH14_DANRE
Q8IZN3, ZDH14_HUMANQ8BQQ1, ZDH14_MOUSEQ5M757, ZDH15_ARATH
Q96MV8, ZDH15_HUMANQ8BGJ0, ZDH15_MOUSEQ2TGJ4, ZDH15_RAT
Q5FWL7, ZDH15_XENLAQ9M115, ZDH16_ARATHQ58CU4, ZDH16_BOVIN
Q969W1, ZDH16_HUMANQ4R7E2, ZDH16_MACFAQ9ESG8, ZDH16_MOUSE
Q8L5Y5, ZDH17_ARATHA5WVX9, ZDH17_DANREQ8IUH5, ZDH17_HUMAN
Q80TN5, ZDH17_MOUSEE9PTT0, ZDH17_RATQ94C49, ZDH18_ARATH
Q9NUE0, ZDH18_HUMANQ5Y5T2, ZDH18_MOUSEQ2TGJ1, ZDH18_RAT
Q9SB58, ZDH19_ARATHQ8WVZ1, ZDH19_HUMANQ810M5, ZDH19_MOUSE
Q500Z2, ZDH20_ARATHQ0VC89, ZDH20_BOVINQ5W0Z9, ZDH20_HUMAN
Q5Y5T1, ZDH20_MOUSEQ5PNZ1, ZDH21_ARATHA2VDT6, ZDH21_BOVIN
B1H1H3, ZDH21_DANREQ8IVQ6, ZDH21_HUMANQ9D270, ZDH21_MOUSE
Q5RB84, ZDH21_PONABQ52T38, ZDH22_ARATHX1WBB5, ZDH22_DANRE
Q8N966, ZDH22_HUMANA0PK84, ZDH22_MOUSEQ2TGI8, ZDH22_RAT
Q9FLM3, ZDH23_ARATHQ8IYP9, ZDH23_HUMANQ5Y5T3, ZDH23_MOUSE
Q76IC6, ZDH23_RATQ8VYS8, ZDH24_ARATHF1QGD2, ZDH24_DANRE
Q6UX98, ZDH24_HUMANQ6IR37, ZDH24_MOUSEQ2TGI5, ZDH24_RAT
A2CEX1, ZDH8B_DANREQ9C533, ZDHC1_ARATHE7F4Z4, ZDHC1_DANRE
Q550R7, ZDHC1_DICDIQ8WTX9, ZDHC1_HUMANQ8R0N9, ZDHC1_MOUSE
Q3EC11, ZDHC2_ARATHQ5BLG4, ZDHC2_DANREQ86A83, ZDHC2_DICDI
Q9UIJ5, ZDHC2_HUMANP59267, ZDHC2_MOUSEQ9JKR5, ZDHC2_RAT
Q6DR03, ZDHC3_ARATHQ557H5, ZDHC3_DICDIQ9NYG2, ZDHC3_HUMAN
Q8R173, ZDHC3_MOUSEQ2TGK3, ZDHC3_RATO80685, ZDHC4_ARATH
Q58DT3, ZDHC4_BOVINF1QAM1, ZDHC4_DANREQ555N7, ZDHC4_DICDI
Q9NPG8, ZDHC4_HUMANQ9D6H5, ZDHC4_MOUSEQ5FVR1, ZDHC4_RAT
Q3EBC2, ZDHC5_ARATHE1BLT8, ZDHC5_BOVINQ2THW9, ZDHC5_CANLF
Q554E7, ZDHC5_DICDIQ9C0B5, ZDHC5_HUMANQ8VDZ4, ZDHC5_MOUSE
Q2THX1, ZDHC5_PANTRQ5R838, ZDHC5_PONABQ2THW7, ZDHC5_RAT
Q93VV0, ZDHC6_ARATHQ2HJ95, ZDHC6_BOVINE7F6D7, ZDHC6_DANRE
Q8T2Q0, ZDHC6_DICDIQ9H6R6, ZDHC6_HUMANQ9CPV7, ZDHC6_MOUSE
Q5REH2, ZDHC6_PONABQ9LIH7, ZDHC7_ARATHQ6DHI1, ZDHC7_DANRE
Q552M6, ZDHC7_DICDIQ9NXF8, ZDHC7_HUMANQ91WU6, ZDHC7_MOUSE
Q923G5, ZDHC7_RATQ9LIE4, ZDHC8_ARATHQ2THW8, ZDHC8_CANLF
Q54VH7, ZDHC8_DICDIQ9W345, ZDHC8_DROMEQ9ULC8, ZDHC8_HUMAN
Q5Y5T5, ZDHC8_MOUSEQ2THX0, ZDHC8_PANTRQ0WQK2, ZDHC9_ARATH
Q58DA8, ZDHC9_BOVINF1R013, ZDHC9_DANREQ9Y397, ZDHC9_HUMAN
P59268, ZDHC9_MOUSEQ5R5J8, ZDHC9_PONABQ5FC64, ZDHCS_CAEEL
P0C7U3, ZH11B_HUMANA0A0R4IDP3, ZH15A_DANREF1QXD3, ZH15B_DANRE

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-