A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.3.1.230

Accepted Name
2-heptyl-4(1H)-quinolone synthase.
Reaction catalysed
Octanoyl-CoA + 2-aminobenzoylacetate <=> 2-heptyl-4(1H)-quinolone + CoA + CO(2) + H(2)O
Comment(s)
  • The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is a heterodimeric complex.
  • The PqsC subunit acquires an octanoyl group from octanoyl-CoA and attaches it to an internal cysteine residue.
  • Together with the PqsB subunit, the proteins catalyze the coupling of the octanoyl group with (2-aminobenzoyl)acetate, leading to decarboxylation and dehydration events that result in closure of the quinoline ring.
Cross-references
BRENDA2.3.1.230
EC2PDB2.3.1.230
ExplorEnz2.3.1.230
PRIAM enzyme-specific profiles2.3.1.230
KEGG Ligand Database for Enzyme Nomenclature2.3.1.230
IUBMB Enzyme Nomenclature2.3.1.230
IntEnz2.3.1.230
MEDLINEFind literature relating to 2.3.1.230
MetaCyc2.3.1.230
UniProtKB/Swiss-Prot
Q9I4X1, PQSC_PSEAE

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-