A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.3.1.230
| Accepted Name |
|---|
| 2-heptyl-4(1H)-quinolone synthase.
|
| Reaction catalysed |
|---|
| Octanoyl-CoA + 2-aminobenzoylacetate <=> 2-heptyl-4(1H)-quinolone + CoA + CO(2) + H(2)O |
| Comment(s) |
|---|
- The enzyme, characterized from the bacterium Pseudomonas aeruginosa,
is a heterodimeric complex.
- The PqsC subunit acquires an octanoyl group from octanoyl-CoA and
attaches it to an internal cysteine residue.
- Together with the PqsB subunit, the proteins catalyze the coupling of
the octanoyl group with (2-aminobenzoyl)acetate, leading to
decarboxylation and dehydration events that result in closure of the
quinoline ring.
|
| Cross-references |
|---|
| BRENDA | 2.3.1.230 |
| EC2PDB | 2.3.1.230 |
| ExplorEnz | 2.3.1.230 |
| PRIAM enzyme-specific profiles | 2.3.1.230 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.230 |
| IUBMB Enzyme Nomenclature | 2.3.1.230 |
| IntEnz | 2.3.1.230 |
| MEDLINE | Find literature relating to 2.3.1.230 |
| MetaCyc | 2.3.1.230 |
| UniProtKB/Swiss-Prot |
|
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