ENZYME entry: EC 2.3.1.230
Accepted Name |
2-heptyl-4(1H)-quinolone synthase.
|
Reaction catalysed |
Octanoyl-CoA + 2-aminobenzoylacetate <=> 2-heptyl-4(1H)-quinolone + CoA + CO(2) + H(2)O |
Comment(s) |
- The enzyme, characterized from the bacterium Pseudomonas aeruginosa,
is a heterodimeric complex.
- The PqsC subunit acquires an octanoyl group from octanoyl-CoA and
attaches it to an internal cysteine residue.
- Together with the PqsB subunit, the proteins catalyze the coupling of
the octanoyl group with (2-aminobenzoyl)acetate, leading to
decarboxylation and dehydration events that result in closure of the
quinoline ring.
|
Cross-references |
BRENDA | 2.3.1.230 |
EC2PDB | 2.3.1.230 |
ExplorEnz | 2.3.1.230 |
PRIAM enzyme-specific profiles | 2.3.1.230 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.230 |
IUBMB Enzyme Nomenclature | 2.3.1.230 |
IntEnz | 2.3.1.230 |
MEDLINE | Find literature relating to 2.3.1.230 |
MetaCyc | 2.3.1.230 |
UniProtKB/Swiss-Prot |
|
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