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ENZYME

ENZYME entry: EC 2.3.1.230

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.230
Accepted Name
2-heptyl-4(1H)-quinolone synthase
Reaction catalysed
(2-aminobenzoyl)acetate + octanoyl-CoA + H(+) = 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O
Comment(s)
  • The enzyme, characterized from the bacterium Pseudomonas aeruginosa, is a heterodimeric complex.
  • The PqsC subunit acquires an octanoyl group from octanoyl-CoA and attaches it to an internal cysteine residue.
  • Together with the PqsB subunit, the proteins catalyze the coupling of the octanoyl group with (2-aminobenzoyl)acetate, leading to decarboxylation and dehydration events that result in closure of the quinoline ring.
Cross-references
Rhea expert-curated reactions2.3.1.230
ExplorEnz2.3.1.230
IUBMB Enzyme Nomenclature2.3.1.230
UniProtKB/Swiss-Prot
Q9I4X1, PQSC_PSEAE
BRENDA2.3.1.230
MetaCyc2.3.1.230
KEGG Ligand Database for Enzyme Nomenclature2.3.1.230
EC2PDB2.3.1.230
MEDLINEFind literature relating to 2.3.1.230

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