ID   2.3.1.239
DE   10-deoxymethynolide syntase.
AN   (2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase
AN   (10-deoxymethynolide forming).
CA   5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH =
CA   10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+).
CC   -!- The product, 10-deoxymethynolide, contains a 12-membered ring and is
CC       an intermediate in the biosynthesis of methymycin in the bacterium
CC       Streptomyces venezuelae.
CC   -!- The enzyme also produces narbonolide (see EC 2.3.1.240).
CC   -!- The enzyme has 29 active sites arranged in four polypeptides (pikAI -
CC       pikAIV) with a loading domain, six extension modules and a terminal
CC       thioesterase domain.
CC   -!- Each extension module contains a ketosynthase (KS), keto reductase
CC       (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP).
CC   -!- Not all active sites are used in the biosynthesis.
DR   Q9ZGI5, PIKA1_STRVZ;  Q9ZGI4, PIKA2_STRVZ;  Q9ZGI3, PIKA3_STRVZ;
DR   Q9ZGI2, PIKA4_STRVZ;
//