Expasy logo

ENZYME

ENZYME entry: EC 2.3.1.243

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.243
Accepted Name
acyl-Kdo2-lipid IVA acyltransferase
Alternative Name(s)
acyl-Kdo2-lipid IVA myristoyltransferase
myristoyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)- (dodecanoyl)-lipid IVA O-myristoyltransferase
Reaction catalysed
an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + a fatty acyl-[ACP] = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]
Comment(s)
  • The enzyme is involved in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A.
  • It transfers an acyl group to the 3-O position of the 3R-hydroxyacyl already attached at the 2-O position of the non-reducing glucosamine molecule.
  • The enzyme from the bacterium Escherichia coli is specific for myristoyl (C14) acyl groups, giving the enzyme its previous accepted name.
  • However, enzymes from different species accept highly variable substrates.
Cross-references
Rhea expert-curated reactions2.3.1.243
ExplorEnz2.3.1.243
IUBMB Enzyme Nomenclature2.3.1.243
UniProtKB/Swiss-Prot
P59198, LPXM1_SHIFLO06659, LPXM2_SHIFLP24205, LPXM_ECOLI
P44567, LPXM_HAEIN
BRENDA2.3.1.243
MetaCyc2.3.1.243
KEGG Ligand Database for Enzyme Nomenclature2.3.1.243
EC2PDB2.3.1.243
MEDLINEFind literature relating to 2.3.1.243

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-