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ENZYME

ENZYME entry: EC 2.3.1.243

Accepted Name
acyl-Kdo2-lipid IVA acyltransferase
Alternative Name(s)
acyl-Kdo2-lipid IVA myristoyltransferase
myristoyl-[acyl-carrier protein]:alpha-Kdo-(2->4)-alpha-Kdo-(2->6)- (dodecanoyl)-lipid IVA O-myristoyltransferase
Reaction catalysed
a fatty acyl-[ACP] + an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA <=> an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]
Comment(s)
  • The enzyme is involved in the biosynthesis of the phosphorylated outer membrane glycolipid lipid A.
  • It transfers an acyl group to the 3-O position of the 3R-hydroxyacyl already attached at the 2-O position of the non-reducing glucosamine molecule.
  • The enzyme from the bacterium Escherichia coli is specific for myristoyl (C14) acyl groups, giving the enzyme its previous accepted name.
  • However, enzymes from different species accept highly variable substrates.
Cross-references
BRENDA2.3.1.243
EC2PDB2.3.1.243
ExplorEnz2.3.1.243
PRIAM enzyme-specific profiles2.3.1.243
KEGG Ligand Database for Enzyme Nomenclature2.3.1.243
IUBMB Enzyme Nomenclature2.3.1.243
IntEnz2.3.1.243
MEDLINEFind literature relating to 2.3.1.243
MetaCyc2.3.1.243
Rhea expert-curated reactions2.3.1.243
UniProtKB/Swiss-Prot
P59198, LPXM1_SHIFLO06659, LPXM2_SHIFLP24205, LPXM_ECOLI
P44567, LPXM_HAEIN

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