ID   2.3.1.244
DE   2-methylbutanoate polyketide synthase.
CA   3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA +
CA   2 NADPH + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-
CA   [2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+)
CA   + S-adenosyl-L-homocysteine.
CC   -!- This polyketide synthase enzyme forms the (S)-2-methylbutanoate side
CC       chain during lovastatin biosynthesis by the filamentous fungus
CC       Aspergillus terreus.
CC   -!- The overall reaction comprises a single condensation reaction
CC       followed by alpha-methylation, beta-ketoreduction, dehydration,
CC       and alpha,beta enoyl reduction.
DR   Q9Y7D5, LOVF_ASPTE ;  Q0C8L6, LOVF_ASPTN ;  Q8J0F5, MLCB_PENCI ;
DR   Q3S2U6, MOKB_MONPI ;
//