ENZYME entry: EC 2.3.1.247

Accepted Name

3-keto-5-aminohexanoate cleavage enzyme

Alternative Name(s)

(5S)-5-amino-3-oxohexanoate:acetyl-CoA ethylamine transferase

Reaction catalysed

(5S)-5-amino-3-oxohexanoate + acetyl-CoA = (3S)-3-aminobutanoyl-CoA + acetoacetate

Comment(s)

Requires Zn(2+).
The enzyme, isolated from the bacteria Fusobacterium nucleatum and Cloacimonas acidaminovorans, belongs to a class of enzymes known as beta-keto acid cleavage enzymes (BKACE).
It is involved in the anaerobic fermentation of lysine. cf. EC 2.3.1.ek, 3-dehydrocarnitine:acetyl-CoA trimethylamine transferase, EC 2.3.1.el, 3-oxoadipate:acetyl-CoA acetyltransferase, and EC 2.3.1.em, 3,5-dioxohexanoate:acetyl-CoA acetone transferase.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

Rhea expert-curated reactions

UniProtKB/Swiss-Prot

E3PRK0, KCE_ACESD

B0VHH0, KCE_CLOAI

Q8RHX2, KCE_FUSNN

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-