A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.3.1.250

Accepted Name
[Wnt protein] O-palmitoleoyl transferase.
Alternative Name(s)
Porcupine.
Reaction catalysed
(9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine <=> CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
Comment(s)
  • The enzyme, found in animals, modifies a specific serine residue in Wnt proteins, e.g. Ser(209) in human Wnt3a and Ser(224) in chicken WNT1.
  • The enzyme can accept C(13) to C(16) fatty acids in vitro, but only (9Z)-hexadecenoate modification is observed in vivo.
  • cf. EC 3.1.1.98.
Cross-references
BRENDA2.3.1.250
EC2PDB2.3.1.250
ExplorEnz2.3.1.250
PRIAM enzyme-specific profiles2.3.1.250
KEGG Ligand Database for Enzyme Nomenclature2.3.1.250
IUBMB Enzyme Nomenclature2.3.1.250
IntEnz2.3.1.250
MEDLINEFind literature relating to 2.3.1.250
MetaCyc2.3.1.250

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-