Expasy logo

ENZYME

ENZYME entry: EC 2.3.1.250

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.250
Accepted Name
[Wnt protein] O-palmitoleoyl transferase
Alternative Name(s)
porcupine
Reaction catalysed
[Wnt protein]-L-serine + (9Z)-hexadecenoyl-CoA = [Wnt protein]-O-(9Z)-hexadecenoyl-L-serine + CoA
Comment(s)
  • The enzyme, found in animals, modifies a specific serine residue in Wnt proteins, e.g. Ser(209) in human Wnt3a and Ser(224) in chicken WNT1.
  • The enzyme can accept C13 to C16 fatty acids in vitro, but only (9Z)- hexadecenoate modification is observed in vivo. cf. EC 3.1.1.98.
Cross-references
Rhea expert-curated reactions2.3.1.250
ExplorEnz2.3.1.250
IUBMB Enzyme Nomenclature2.3.1.250
UniProtKB/Swiss-Prot
Q7Q3N5, PORCN_ANOGAA8WZ09, PORCN_CAEBRQ22329, PORCN_CAEEL
Q9VWV9, PORCN_DROMEQ9H237, PORCN_HUMANQ9JJJ7, PORCN_MOUSE
BRENDA2.3.1.250
MetaCyc2.3.1.250
KEGG Ligand Database for Enzyme Nomenclature2.3.1.250
EC2PDB2.3.1.250
MEDLINEFind literature relating to 2.3.1.250

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-