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ENZYME entry: EC 2.3.1.250

Accepted Name
[Wnt protein] O-palmitoleoyl transferase.
Alternative Name(s)
Porcupine.
Reaction catalysed
(9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine <=> CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
Comment(s)
  • The enzyme, found in animals, modifies a specific serine residue in Wnt proteins, e.g. Ser(209) in human Wnt3a and Ser(224) in chicken WNT1.
  • The enzyme can accept C(13) to C(16) fatty acids in vitro, but only (9Z)-hexadecenoate modification is observed in vivo.
  • cf. EC 3.1.1.98.
Cross-references
BRENDA2.3.1.250
EC2PDB2.3.1.250
ExplorEnz2.3.1.250
PRIAM enzyme-specific profiles2.3.1.250
KEGG Ligand Database for Enzyme Nomenclature2.3.1.250
IUBMB Enzyme Nomenclature2.3.1.250
IntEnz2.3.1.250
MEDLINEFind literature relating to 2.3.1.250
MetaCyc2.3.1.250
UniProtKB/Swiss-Prot
Q7Q3N5, PORCN_ANOGA;  A8WZ09, PORCN_CAEBR;  Q22329, PORCN_CAEEL;  
Q9VWV9, PORCN_DROME;  Q9H237, PORCN_HUMAN;  Q9JJJ7, PORCN_MOUSE;  

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