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ENZYME

ENZYME entry: EC 2.3.1.251

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.251
Accepted Name
lipid IVA palmitoyltransferase
Reaction catalysed
  • lipid A (E. coli) + a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine = hepta-acyl lipid A (E. coli) + a 2-acyl-sn-glycero-3-phosphocholine
  • lipid IIA + a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine = lipid IIB + a 2-acyl-sn-glycero-3-phosphocholine
  • lipid IVA (E. coli) + a 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphocholine = lipid IVB (E. coli) + a 2-acyl-sn-glycero-3-phosphocholine
Comment(s)
  • Isolated from the bacteria Escherichia coli and Salmonella typhimurium.
  • The enzyme prefers phosphatidylcholine with a palmitoyl group at the sn-1 position and palmitoyl or stearoyl groups at the sn-2 position.
  • There is some activity with corresponding phosphatidylserines but only weak activity with other diacylphosphatidyl compounds.
  • The enzyme also acts on Kdo-(2->4)-Kdo-(2->6)-lipid IVA.
Cross-references
BRENDA2.3.1.251
EC2PDB2.3.1.251
ExplorEnz2.3.1.251
KEGG Ligand Database for Enzyme Nomenclature2.3.1.251
IUBMB Enzyme Nomenclature2.3.1.251
MEDLINEFind literature relating to 2.3.1.251
MetaCyc2.3.1.251
Rhea expert-curated reactions2.3.1.251
UniProtKB/Swiss-Prot
Q7WFT9, PAGP_BORBRQ7W4D1, PAGP_BORPAF4LAC2, PAGP_BORPC
Q7VUS0, PAGP_BORPEA8AJI1, PAGP_CITK8D2TMR7, PAGP_CITRI
A7MNQ4, PAGP_CROS8Q3ZUY0, PAGP_CROSKC9XYQ1, PAGP_CROTZ
C6CNE4, PAGP_DICC1E0SLJ5, PAGP_DICD3D2C1B0, PAGP_DICZ5
Q8XBR9, PAGP_ECO57E8Y6Y6, PAGP_ECOKOQ0TK50, PAGP_ECOL5
Q8FJZ7, PAGP_ECOL6P37001, PAGP_ECOLIE0J1Q4, PAGP_ECOLW
Q1RET8, PAGP_ECOUTD0ZCI3, PAGP_EDWPIE0T5K2, PAGP_EDWTF
D6DRS2, PAGP_ENTCLE3G4M5, PAGP_ENTLSD4HYT3, PAGP_ERWAC
D4I8K8, PAGP_ERWAED2T3S6, PAGP_ERWP6D0FUE8, PAGP_ERWPE
E3DK69, PAGP_ERWSEB2VBK5, PAGP_ERWT9A6T684, PAGP_KLEP7
C1D6F2, PAGP_LARHHD3HNB4, PAGP_LEGLND5T5P7, PAGP_LEGP2
Q5X966, PAGP_LEGPAA5I9H6, PAGP_LEGPCQ5ZZI5, PAGP_LEGPH
Q5X0J3, PAGP_LEGPLQ93K12, PAGP_LEGPNQ1H2L0, PAGP_METFK
C6C6T1, PAGP_MUSP7F2EP14, PAGP_PANAAD4GM10, PAGP_PANAM
Q6DAS8, PAGP_PECASC6DIA0, PAGP_PECCPD0KD36, PAGP_PECPW
C7BTJ1, PAGP_PHOAAQ7N3D3, PAGP_PHOLLB4EYA9, PAGP_PROMH
Q5PM92, PAGP_SALPAC0PW57, PAGP_SALPCQ8Z8I4, PAGP_SALTI
Q8ZR06, PAGP_SALTYA8GAF7, PAGP_SERP5Q324S0, PAGP_SHIBS
D2AA19, PAGP_SHIF2Q0T6N3, PAGP_SHIF8Q83LW9, PAGP_SHIFL
Q2NSM3, PAGP_SODGMA1JM47, PAGP_YERE8Q1C8Y7, PAGP_YERPA
B2K0E2, PAGP_YERPBQ8D091, PAGP_YERPEQ1CH24, PAGP_YERPN
D5B7J8, PAGP_YERPZ

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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