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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.3.1.251

Accepted Name
Lipid IV(A) palmitoyltransferase.
Reaction catalysed
  • 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A <=> 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
  • 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid II(A) <=> 2-acyl-sn-glycero-3-phosphocholine + lipid II(B)
  • 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IV(A) <=> 2-acyl-sn-glycero-3-phosphocholine + lipid IV(B)
Comment(s)
  • Isolated from the bacteria Escherichia coli and Salmonella typhimurium.
  • The enzyme prefers phosphatidylcholine with a palmitoyl group at the sn-1 position and palmitoyl or stearoyl groups at the sn-2 position.
  • There is some activity with corresponding phosphatidylserines but only weak activity with other diacylphosphatidyl compounds.
  • The enzyme also acts on Kdo-(2->4)-Kdo-(2->6)-lipid IV(A).
Cross-references
BRENDA2.3.1.251
EC2PDB2.3.1.251
ExplorEnz2.3.1.251
PRIAM enzyme-specific profiles2.3.1.251
KEGG Ligand Database for Enzyme Nomenclature2.3.1.251
IUBMB Enzyme Nomenclature2.3.1.251
IntEnz2.3.1.251
MEDLINEFind literature relating to 2.3.1.251
MetaCyc2.3.1.251
UniProtKB/Swiss-Prot
Q7WFT9, PAGP_BORBR;  Q7W4D1, PAGP_BORPA;  F4LAC2, PAGP_BORPC;  
Q7VUS0, PAGP_BORPE;  A8AJI1, PAGP_CITK8;  D2TMR7, PAGP_CITRI;  
A7MNQ4, PAGP_CROS8;  Q3ZUY0, PAGP_CROSK;  C9XYQ1, PAGP_CROTZ;  
C6CNE4, PAGP_DICC1;  E0SLJ5, PAGP_DICD3;  C6C6T1, PAGP_DICP7;  
D2C1B0, PAGP_DICZ5;  Q8XBR9, PAGP_ECO57;  E8Y6Y6, PAGP_ECOKO;  
Q0TK50, PAGP_ECOL5;  Q8FJZ7, PAGP_ECOL6;  P37001, PAGP_ECOLI;  
E0J1Q4, PAGP_ECOLW;  Q1RET8, PAGP_ECOUT;  D0ZCI3, PAGP_EDWTE;  
E0T5K2, PAGP_EDWTF;  D6DRS2, PAGP_ENTCL;  E3G4M5, PAGP_ENTLS;  
D4HYT3, PAGP_ERWAC;  D4I8K8, PAGP_ERWAE;  D2T3S6, PAGP_ERWP6;  
D0FUE8, PAGP_ERWPE;  E3DK69, PAGP_ERWSE;  B2VBK5, PAGP_ERWT9;  
A6T684, PAGP_KLEP7;  C1D6F2, PAGP_LARHH;  D3HNB4, PAGP_LEGLN;  
D5T5P7, PAGP_LEGP2;  Q5X966, PAGP_LEGPA;  A5I9H6, PAGP_LEGPC;  
Q5ZZI5, PAGP_LEGPH;  Q5X0J3, PAGP_LEGPL;  Q93K12, PAGP_LEGPN;  
Q1H2L0, PAGP_METFK;  F2EP14, PAGP_PANAA;  D4GM10, PAGP_PANAM;  
Q6DAS8, PAGP_PECAS;  C6DIA0, PAGP_PECCP;  D0KD36, PAGP_PECPW;  
C7BTJ1, PAGP_PHOAA;  Q7N3D3, PAGP_PHOLL;  B4EYA9, PAGP_PROMH;  
Q5PM92, PAGP_SALPA;  C0PW57, PAGP_SALPC;  Q8Z8I4, PAGP_SALTI;  
Q8ZR06, PAGP_SALTY;  A8GAF7, PAGP_SERP5;  Q324S0, PAGP_SHIBS;  
D2AA19, PAGP_SHIF2;  Q0T6N3, PAGP_SHIF8;  Q83LW9, PAGP_SHIFL;  
Q2NSM3, PAGP_SODGM;  A1JM47, PAGP_YERE8;  Q1C8Y7, PAGP_YERPA;  
B2K0E2, PAGP_YERPB;  Q8D091, PAGP_YERPE;  Q1CH24, PAGP_YERPN;  
D5B7J8, PAGP_YERPZ;  

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