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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Mycolipanoate synthase.
Alternative Name(s)
Mycolipanoic acid synthase.
Reaction catalysed
A long-chain acyl-CoA + 3 (S)-methylmalonyl-CoA + 6 NADPH + holo-[mycolipanoate synthase] <=> mycolipanoyl-[mycolipanoate synthase] + 4 CoA + 3 CO(2) + 6 NADP(+) + 3 H(2)O
  • This mycobacterial enzyme accepts long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three methylmalonyl (but not malonyl) residues, forming trimethyl-branched fatty-acids such as (2S,4S,6S)-2,4,6-trimethyl-tetracosanoate (C(27)- mycolipanoate).
  • Since the enzyme lacks a thioesterase domain, the product remains bound to the enzyme and requires additional enzyme(s) for removal.
PRIAM enzyme-specific profiles2.3.1.252
KEGG Ligand Database for Enzyme Nomenclature2.3.1.252
IUBMB Enzyme Nomenclature2.3.1.252
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