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ENZYME entry: EC 2.3.1.252

Accepted Name
mycolipanoate synthase
Alternative Name(s)
mycolipanoic acid synthase
Reaction catalysed
3 (S)-methylmalonyl-CoA + a long-chain fatty acyl-CoA + 9 H(+) + holo-[mycolipanoate synthase] + 6 NADPH <=> 3 CO2 + 4 CoA + 3 H2O + long-chain mycolipanoyl-[mycolipanoate synthase] + 6 NADP(+)
Comment(s)
  • This mycobacterial enzyme accepts long-chain fatty acyl groups from their CoA esters and extends them by incorporation of three methylmalonyl (but not malonyl) residues, forming trimethyl-branched fatty-acids such as (2S,4S,6S)-2,4,6-trimethyl-tetracosanoate (C27- mycolipanoate).
  • Since the enzyme lacks a thioesterase domain, the product remains bound to the enzyme and requires additional enzyme(s) for removal.
Cross-references
BRENDA2.3.1.252
EC2PDB2.3.1.252
ExplorEnz2.3.1.252
PRIAM enzyme-specific profiles2.3.1.252
KEGG Ligand Database for Enzyme Nomenclature2.3.1.252
IUBMB Enzyme Nomenclature2.3.1.252
IntEnz2.3.1.252
MEDLINEFind literature relating to 2.3.1.252
MetaCyc2.3.1.252
Rhea expert-curated reactions2.3.1.252
UniProtKB/Swiss-Prot
A0A089QRB9, MSL3_MYCTU

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