ENZYME entry: EC 2.3.1.252
Accepted Name |
Mycolipanoate synthase.
|
Alternative Name(s) |
Mycolipanoic acid synthase. |
Reaction catalysed |
A long-chain acyl-CoA + 3 (S)-methylmalonyl-CoA + 6 NADPH + holo-[mycolipanoate synthase] <=> mycolipanoyl-[mycolipanoate synthase] + 4 CoA + 3 CO(2) + 6 NADP(+) + 3 H(2)O |
Comment(s) |
- This mycobacterial enzyme accepts long-chain fatty acyl groups from
their CoA esters and extends them by incorporation of three
methylmalonyl (but not malonyl) residues, forming trimethyl-branched
fatty-acids such as (2S,4S,6S)-2,4,6-trimethyl-tetracosanoate (C(27)-
mycolipanoate).
- Since the enzyme lacks a thioesterase domain, the product remains
bound to the enzyme and requires additional enzyme(s) for removal.
|
Cross-references |
BRENDA | 2.3.1.252 |
EC2PDB | 2.3.1.252 |
ExplorEnz | 2.3.1.252 |
PRIAM enzyme-specific profiles | 2.3.1.252 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.252 |
IUBMB Enzyme Nomenclature | 2.3.1.252 |
IntEnz | 2.3.1.252 |
MEDLINE | Find literature relating to 2.3.1.252 |
MetaCyc | 2.3.1.252 |
Rhea expert-curated reactions | 2.3.1.252 |
UniProtKB/Swiss-Prot |
|
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