A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.3.1.252
| Accepted Name |
|---|
| Mycolipanoate synthase.
|
| Alternative Name(s) |
|---|
| Mycolipanoic acid synthase. |
| Reaction catalysed |
|---|
| A long-chain acyl-CoA + 3 (S)-methylmalonyl-CoA + 6 NADPH + holo-[mycolipanoate synthase] <=> mycolipanoyl-[mycolipanoate synthase] + 4 CoA + 3 CO(2) + 6 NADP(+) + 3 H(2)O |
| Comment(s) |
|---|
- This mycobacterial enzyme accepts long-chain fatty acyl groups from
their CoA esters and extends them by incorporation of three
methylmalonyl (but not malonyl) residues, forming trimethyl-branched
fatty-acids such as (2S,4S,6S)-2,4,6-trimethyl-tetracosanoate (C(27)-
mycolipanoate).
- Since the enzyme lacks a thioesterase domain, the product remains
bound to the enzyme and requires additional enzyme(s) for removal.
|
| Cross-references |
|---|
| BRENDA | 2.3.1.252 |
| EC2PDB | 2.3.1.252 |
| ExplorEnz | 2.3.1.252 |
| PRIAM enzyme-specific profiles | 2.3.1.252 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.252 |
| IUBMB Enzyme Nomenclature | 2.3.1.252 |
| IntEnz | 2.3.1.252 |
| MEDLINE | Find literature relating to 2.3.1.252 |
| MetaCyc | 2.3.1.252 |
| UniProtKB/Swiss-Prot |
|
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UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-