ID   2.3.1.253
DE   phloroglucinol synthase.
CA   3 H(+) + 3 malonyl-CoA = 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA.
CC   -!- The enzyme, characterized from the bacterium Pseudomonas protegens
CC       Pf-5, is a type III polyketide synthase.
CC   -!- The mechanism involves the cyclization of an activated 3,5-
CC       dioxoheptanedioate intermediate.
CC   -!- The enzyme exhibits broad substrate specificity, and can accept
CC       C4-C12 aliphatic acyl-CoAs and phenylacetyl-CoA as the starter
CC       molecules, forming C(6)-polyoxoalkylated alpha-pyrones by sequential
CC       condensation with malonyl-CoA.
DR   Q4K418, PHLD_PSEF5 ;  Q51725, PHLD_PSEFL ;
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