Home  |  Contact

ENZYME entry: EC 2.3.1.254

Accepted Name
N-terminal methionine N(alpha)-acetyltransferase NatB.
Reaction catalysed
  • Acetyl-CoA + an N-terminal L-methionyl-L-asparaginyl-[protein] <=> an N-terminal N(alpha)-acetyl-L-methionyl-L-asparginyl-[protein] + CoA
  • Acetyl-CoA + an N-terminal L-methionyl-L-glutaminyl-[protein] <=> an N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA
  • Acetyl-CoA + an N-terminal L-methionyl-L-aspartyl-[protein] <=> an N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] + CoA
  • Acetyl-CoA + an N-terminal L-methionyl-L-glutamyl-[protein] <=> an N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] + CoA
Comment(s)
  • N-terminal acetylases (NATs) catalyze the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein.
  • This irreversible modification neutralizes the positive charge at the N-terminus and makes the N-terminal residue larger and more hydrophobic, and may also play a role in membrane targeting and gene silencing.
  • The NatB complex is found in all eukaryotic organisms, and specifically targets N-terminal L-methionine residues attached to Asn, Asp, Gln, or Glu residues at the second position.
  • Formerly EC 2.3.1.88.
Cross-references
BRENDA2.3.1.254
EC2PDB2.3.1.254
ExplorEnz2.3.1.254
PRIAM enzyme-specific profiles2.3.1.254
KEGG Ligand Database for Enzyme Nomenclature2.3.1.254
IUBMB Enzyme Nomenclature2.3.1.254
IntEnz2.3.1.254
MEDLINEFind literature relating to 2.3.1.254
MetaCyc2.3.1.254
UniProtKB/Swiss-Prot
Q8LGI8, NAA20_ARATH;  Q58ED9, NAA20_DANRE;  P61599, NAA20_HUMAN;  
Q2PFM2, NAA20_MACFA;  P61600, NAA20_MOUSE;  Q7ZXR3, NAA20_XENLA;  
Q6P632, NAA20_XENTR;  O74457, NAT3_SCHPO;  Q06504, NAT3_YEAST;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-